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Targeting of neuroblastoma cells through Kynurenine-AHR pathway inhibition.
Dos Santos IL, Mitchell M, Nogueira PAS, Lafita-Navarro MC, Perez-Castro L, Eriom J, Kilgore JA, Williams NS, Guo L, Xu L, Conacci-Sorrell M. Dos Santos IL, et al. Among authors: xu l. FEBS J. 2024 May;291(10):2172-2190. doi: 10.1111/febs.17109. Epub 2024 Mar 3. FEBS J. 2024. PMID: 38431776
The AHR target gene scinderin activates the WNT pathway by facilitating the nuclear translocation of β-catenin.
Perez-Castro L, Venkateswaran N, Garcia R, Hao YH, Lafita-Navarro MC, Kim J, Segal D, Saponzik E, Chang BJ, Fiolka R, Danuser G, Xu L, Brabletz T, Conacci-Sorrell M. Perez-Castro L, et al. Among authors: xu l. J Cell Sci. 2022 Oct 15;135(20):jcs260028. doi: 10.1242/jcs.260028. Epub 2022 Oct 27. J Cell Sci. 2022. PMID: 36148682 Free PMC article.
WILMS TUMOR MUTATIONAL SUBCLASSES CONVERGE TO DRIVE CCND2 OVEREXPRESSION.
Xu L, Desai K, Kim J, Zhou Q, Guo L, Xiao X, Zhang Y, Zhou L, Yuksel A, Catchpoole DR, Amatruda JF, Chen KS. Xu L, et al. medRxiv [Preprint]. 2023 Feb 2:2023.01.30.23285117. doi: 10.1101/2023.01.30.23285117. medRxiv. 2023. PMID: 36778325 Free PMC article. Preprint.
TWIST2-mediated chromatin remodeling promotes fusion-negative rhabdomyosarcoma.
Shah AM, Guo L, Morales MG, Jaichander P, Chen K, Huang H, Cano Hernandez K, Xu L, Bassel-Duby R, Olson EN, Liu N. Shah AM, et al. Among authors: xu l. Sci Adv. 2023 Apr 28;9(17):eade8184. doi: 10.1126/sciadv.ade8184. Epub 2023 Apr 28. Sci Adv. 2023. PMID: 37115930 Free PMC article.
Protein arginine methyltransferase 5 (PRMT5) is an actionable therapeutic target in CDK4/6 inhibitor-resistant ER+/RB-deficient breast cancer.
Lin CC, Chang TC, Wang Y, Guo L, Gao Y, Bikorimana E, Lemoff A, Fang YV, Zhang H, Zhang Y, Ye D, Soria-Bretones I, Servetto A, Lee KM, Luo X, Otto JJ, Akamatsu H, Napolitano F, Mani R, Cescon DW, Xu L, Xie Y, Mendell JT, Hanker AB, Arteaga CL. Lin CC, et al. Among authors: xu l. Res Sq [Preprint]. 2023 Jul 10:rs.3.rs-2966905. doi: 10.21203/rs.3.rs-2966905/v1. Res Sq. 2023. Update in: Nat Commun. 2024 Mar 13;15(1):2287. doi: 10.1038/s41467-024-46495-2 PMID: 37502925 Free PMC article. Updated. Preprint.
ZNF692 organizes a hub specialized in 40S ribosomal subunit maturation enhancing translation in rapidly proliferating cells.
Lafita-Navarro MC, Hao YH, Jiang C, Jang S, Chang TC, Brown IN, Venkateswaran N, Maurais E, Stachera W, Zhang Y, Mundy D, Han J, Tran VM, Mettlen M, Xu L, Woodruff JB, Grishin NV, Kinch L, Mendell JT, Buszczak M, Conacci-Sorrell M. Lafita-Navarro MC, et al. Among authors: xu l. Cell Rep. 2023 Oct 31;42(10):113280. doi: 10.1016/j.celrep.2023.113280. Epub 2023 Oct 16. Cell Rep. 2023. PMID: 37851577 Free PMC article.
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