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Efficacy and safety results after >3.5 years of treatment with the Bruton's tyrosine kinase inhibitor evobrutinib in relapsing multiple sclerosis: Long-term follow-up of a Phase II randomised clinical trial with a cerebrospinal fluid sub-study.
Montalban X, Piasecka-Stryczynska K, Kuhle J, Benkert P, Arnold DL, Weber MS, Seitzinger A, Guehring H, Shaw J, Tomic D, Hyvert Y, Harlow DE, Dyroff M, Wolinsky JS. Montalban X, et al. Among authors: dyroff m. Mult Scler. 2024 Apr;30(4-5):558-570. doi: 10.1177/13524585241234783. Epub 2024 Mar 4. Mult Scler. 2024. PMID: 38436271 Free PMC article. Clinical Trial.
Pyridazinoquinolinetriones as NMDA glycine-site antagonists with oral antinociceptive activity in a model of neuropathic pain.
Bare TM, Brown DG, Horchler CL, Murphy M, Urbanek RA, Alford V, Barlaam C, Dyroff MC, Empfield JB, Forst JM, Herzog KJ, Keith RA, Kirschner AS, Lee CM, Lewis J, McLaren FM, Neilson KL, Steelman GB, Trivedi S, Vacek EP, Xiao W. Bare TM, et al. Among authors: dyroff mc. J Med Chem. 2007 Jun 28;50(13):3113-31. doi: 10.1021/jm060212s. Epub 2007 Jun 2. J Med Chem. 2007. PMID: 17542571
Synthesis of 7-chloro-2,3-dihydro-2-[1-(pyridinyl)alkyl]-pyridazino[4,5-b]quinoline-1,4,10(5H)-triones as NMDA glycine-site antagonists.
Brown DG, Urbanek RA, Bare TM, McLaren FM, Horchler CL, Murphy M, Steelman GB, Empfield JR, Forst JM, Herzog KJ, Xiao W, Dyroff MC, Lee CM, Trivedi S, Neilson KL, Keith RA. Brown DG, et al. Among authors: dyroff mc. Bioorg Med Chem Lett. 2003 Oct 20;13(20):3553-6. doi: 10.1016/s0960-894x(03)00750-9. Bioorg Med Chem Lett. 2003. PMID: 14505669
28 results