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The Onpattro story and the clinical translation of nanomedicines containing nucleic acid-based drugs.
Akinc A, Maier MA, Manoharan M, Fitzgerald K, Jayaraman M, Barros S, Ansell S, Du X, Hope MJ, Madden TD, Mui BL, Semple SC, Tam YK, Ciufolini M, Witzigmann D, Kulkarni JA, van der Meel R, Cullis PR. Akinc A, et al. Among authors: cullis pr. Nat Nanotechnol. 2019 Dec;14(12):1084-1087. doi: 10.1038/s41565-019-0591-y. Nat Nanotechnol. 2019. PMID: 31802031 No abstract available.
Lipid nanoparticle technology for therapeutic gene regulation in the liver.
Witzigmann D, Kulkarni JA, Leung J, Chen S, Cullis PR, van der Meel R. Witzigmann D, et al. Among authors: cullis pr. Adv Drug Deliv Rev. 2020;159:344-363. doi: 10.1016/j.addr.2020.06.026. Epub 2020 Jul 2. Adv Drug Deliv Rev. 2020. PMID: 32622021 Free PMC article. Review.
The Biomolecular Corona of Lipid Nanoparticles for Gene Therapy.
Francia V, Schiffelers RM, Cullis PR, Witzigmann D. Francia V, et al. Among authors: cullis pr. Bioconjug Chem. 2020 Sep 16;31(9):2046-2059. doi: 10.1021/acs.bioconjchem.0c00366. Epub 2020 Aug 31. Bioconjug Chem. 2020. PMID: 32786370 Review.
Altering the intra-liver distribution of phospholipid-free small unilamellar vesicles using temperature-dependent size-tunability.
Vogler J, Böttger R, Al Fayez N, Zhang W, Qin Z, Hohenwarter L, Chao PH, Rouhollahi E, Bilal N, Chen N, Lee B, Chen C, Wilkinson B, Kieffer TJ, Kulkarni JA, Cullis PR, Witzigmann D, Li SD. Vogler J, et al. Among authors: cullis pr. J Control Release. 2021 May 10;333:151-161. doi: 10.1016/j.jconrel.2021.03.025. Epub 2021 Mar 23. J Control Release. 2021. PMID: 33771624
314 results