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Lipid nanoparticle structure and delivery route during pregnancy dictate mRNA potency, immunogenicity, and maternal and fetal outcomes.
Chaudhary N, Newby AN, Arral ML, Yerneni SS, LoPresti ST, Doerfler R, Petersen DMS, Montoya C, Kim JS, Fox B, Coon T, Malaney A, Sadovsky Y, Whitehead KA. Chaudhary N, et al. Among authors: whitehead ka. Proc Natl Acad Sci U S A. 2024 Mar 12;121(11):e2307810121. doi: 10.1073/pnas.2307810121. Epub 2024 Mar 4. Proc Natl Acad Sci U S A. 2024. PMID: 38437545 Free PMC article.
The strawberry-derived permeation enhancer pelargonidin enables oral protein delivery.
Lamson NG, Fein KC, Gleeson JP, Newby AN, Xian S, Cochran K, Chaudhary N, Melamed JR, Ball RL, Suri K, Ahuja V, Zhang A, Berger A, Kolodieznyi D, Schmidt BF, Silva GL, Whitehead KA. Lamson NG, et al. Among authors: whitehead ka. Proc Natl Acad Sci U S A. 2022 Aug 16;119(33):e2207829119. doi: 10.1073/pnas.2207829119. Epub 2022 Aug 9. Proc Natl Acad Sci U S A. 2022. PMID: 35943988 Free PMC article.
130 results