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Basophil: The cell that itches.
Das M, Leyva-Castillo JM, Geha RS. Das M, et al. J Allergy Clin Immunol. 2021 Sep;148(3):708-709. doi: 10.1016/j.jaci.2021.06.010. Epub 2021 Jun 17. J Allergy Clin Immunol. 2021. PMID: 34147536 No abstract available.
Combined immunodeficiency with autoimmunity caused by a homozygous missense mutation in inhibitor of nuclear factor 𝛋B kinase alpha (IKKα).
Bainter W, Lougaris V, Wallace JG, Badran Y, Hoyos-Bachiloglu R, Peters Z, Wilkie H, Das M, Janssen E, Beano A, Farhat KB, Kam C, Bercich L, Incardona P, Villanacci V, Bondioni MP, Meini A, Baronio M, Abarzua P, Parolini S, Tabellini G, Maio S, Schmidt B, Goldsmith JD, Murphy G, Hollander G, Plebani A, Chou J, Geha RS. Bainter W, et al. Among authors: das m. Sci Immunol. 2021 Sep 17;6(63):eabf6723. doi: 10.1126/sciimmunol.abf6723. Epub 2021 Sep 17. Sci Immunol. 2021. PMID: 34533979 Free PMC article.
Basophil-derived IL-4 promotes cutaneous Staphylococcus aureus infection.
Leyva-Castillo JM, Das M, Kane J, Strakosha M, Singh S, Wong DSH, Horswill AR, Karasuyama H, Brombacher F, Miller LS, Geha RS. Leyva-Castillo JM, et al. Among authors: das m. JCI Insight. 2021 Nov 8;6(21):e149953. doi: 10.1172/jci.insight.149953. JCI Insight. 2021. PMID: 34747366 Free PMC article.
The IL-4Rα Q576R polymorphism is associated with increased severity of atopic dermatitis and exaggerates allergic skin inflammation in mice.
Yang B, Wilkie H, Das M, Timilshina M, Bainter W, Woods B, Daya M, Boorgula MP, Mathias RA, Lai P, Petty CR, Weller E, Harb H, Chatila TA, Leung DYM, Beck LA, Simpson EL, Hata TR, Barnes KC, Phipatanakul W, Leyva-Castillo JM, Geha RS. Yang B, et al. Among authors: das m. J Allergy Clin Immunol. 2023 May;151(5):1296-1306.e7. doi: 10.1016/j.jaci.2023.01.011. Epub 2023 Jan 21. J Allergy Clin Immunol. 2023. PMID: 36690254 Free PMC article.
Regulatory T-cell dysfunction and cutaneous exposure to Staphylococcus aureus underlie eczema in DOCK8 deficiency.
Wilkie H, Das M, Pelovitz T, Bainter W, Woods B, Alasharee M, Sobh A, Baris S, Eltan SB, Al-Herz W, Barbouche MR, Ben-Mustapha I, Ben-Ali M, Sallam MTH, Awad A, Lotfy S, El Marsafy A, Ezzelarab M, Farrar M, Schmidt BAR, NandyMazumdar M, Guttman-Yassky E, Sheets A, Vidic KM, Murphy G, Schlievert PM, Chou J, Leyva-Castillo JM, Janssen E, Timilshina M, Geha RS. Wilkie H, et al. Among authors: das m. J Allergy Clin Immunol. 2024 Jul;154(1):143-156. doi: 10.1016/j.jaci.2023.12.020. Epub 2024 Jan 5. J Allergy Clin Immunol. 2024. PMID: 38185418
IL-4 acts on skin-derived dendritic cells to promote the TH2 response to cutaneous sensitization and the development of allergic skin inflammation.
Leyva-Castillo JM, Das M, Strakosha M, McGurk A, Artru E, Kam C, Alasharee M, Wesemann DR, Tomura M, Karasuyama H, Brombacher F, Geha RS. Leyva-Castillo JM, et al. Among authors: das m. J Allergy Clin Immunol. 2024 Dec;154(6):1462-1471.e3. doi: 10.1016/j.jaci.2024.06.021. Epub 2024 Jul 10. J Allergy Clin Immunol. 2024. PMID: 38996877
3,921 results