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226 results

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Discovery of 4-(4-aminophenyl)-6-phenylisoxazolo[3,4-b]pyridine-3-amine derivatives as novel FLT3 covalent inhibitors for the intervention of acute myeloid leukemia.
Wang QX, Wang YB, Sha JK, Zhou H, Liu JC, Wu JZ, Tong ZJ, Cai J, Chen ZJ, Zhang CQ, Zheng XR, Wang JJ, Wang XL, Xue X, Yu YC, Ding N, Leng XJ, Dai WC, Sun SL, Chang L, Li NG, Shi ZH. Wang QX, et al. Among authors: li ng. Drug Dev Res. 2023 Apr;84(2):296-311. doi: 10.1002/ddr.22032. Epub 2023 Jan 16. Drug Dev Res. 2023. PMID: 36644989
Design and synthesis of selective FLT3 inhibitors via exploration of back pocket II.
Wang QX, Cao YH, Yang LJ, Ma YY, Li N, Wu SH, Chen L, Wu JZ, Tong ZJ, Wang XL, Xue X, Ding N, Leng XJ, Chang L, Dai WC, Yu YC, Sun SL, Yang Y, Li NG, Shi ZH. Wang QX, et al. Among authors: li n, li ng. Future Med Chem. 2023 Jan;15(1):57-71. doi: 10.4155/fmc-2022-0231. Epub 2023 Jan 18. Future Med Chem. 2023. PMID: 36651264
Correction to "Discovery of RORγ Allosteric Fluorescent Probes and Their Application: Fluorescence Polarization, Screening, and Bioimaging".
Yu YC, Tong ZJ, Liang XT, Wu JZ, Xu YJ, Wang JJ, Zhang MY, Wei TH, Yang J, Wang YB, Wang QX, Li QQ, Wang ZX, Leng XJ, Ding N, Xue X, Sun SL, Li NG, Wang XL. Yu YC, et al. Among authors: li qq, li ng. J Med Chem. 2024 Apr 11;67(7):5960-5961. doi: 10.1021/acs.jmedchem.4c00606. Epub 2024 Mar 26. J Med Chem. 2024. PMID: 38530955 No abstract available.
Exploring drug repositioning possibilities of kinase inhibitors via molecular simulation.
Wang QX, Cai J, Chen ZJ, Liu JC, Wang JJ, Zhou H, Li QQ, Wang ZX, Wang YB, Tong ZJ, Yang J, Wei TH, Zhang MY, Zhou Y, Dai WC, Ding N, Leng XJ, Yin XY, Sun SL, Yu YC, Li NG, Shi ZH. Wang QX, et al. Among authors: li qq, li ng. Mol Inform. 2024 Sep;43(9):e202300336. doi: 10.1002/minf.202300336. Epub 2024 Jun 21. Mol Inform. 2024. PMID: 39031899
Discovery of SILA-123 as a Highly Potent FLT3 Inhibitor for the Treatment of Acute Myeloid Leukemia with Various FLT3 Mutations.
Wei TH, Wang ZX, Lu MY, Xu YJ, Yang J, Ni XF, Cheng Y, Zhang MY, Liu JC, Li QQ, Cai J, Chen ZJ, Kang JB, Li N, Dai WC, Ding N, Yu YC, Leng XJ, Xue X, Wang XL, Sun SL, Yang Y, Li NG, Shi ZH. Wei TH, et al. Among authors: li ng. J Med Chem. 2024 Dec 26;67(24):21752-21780. doi: 10.1021/acs.jmedchem.4c00529. Epub 2024 Sep 11. J Med Chem. 2024. PMID: 39258312
226 results