O'Regan L - Search Results

1

The mesenchymal morphology of cells expressing the EML4-ALK V3 oncogene is dependent on phosphorylation of Eg5 by NEK7.

Pashley SL, Papageorgiou S, O'Regan L, Barone G, Robinson SW, Lucken K, Straatman KR, Roig J, Fry AM. Pashley SL, et al. Among authors: o regan l. J Biol Chem. 2024 May;300(5):107144. doi: 10.1016/j.jbc.2024.107144. Epub 2024 Mar 6. J Biol Chem. 2024. PMID: 38458397 Free PMC article.

2

Implications of CD34+ cell dose on clinical and haematological outcome of allo-SCT for acquired aplastic anaemia.

Islam MS, Anoop P, Datta-Nemdharry P, Sage D, Gordon-Smith EC, Turner D, Wiltshire S, O'Regan L, Marsh JC. Islam MS, et al. Bone Marrow Transplant. 2010 May;45(5):886-94. doi: 10.1038/bmt.2009.267. Epub 2009 Oct 12. Bone Marrow Transplant. 2010. PMID: 19820727

3

Mitotic regulation by NIMA-related kinases.

O'regan L, Blot J, Fry AM. O'regan L, et al. Cell Div. 2007 Aug 29;2:25. doi: 10.1186/1747-1028-2-25. Cell Div. 2007. PMID: 17727698 Free PMC article.

4

The Nek6 and Nek7 protein kinases are required for robust mitotic spindle formation and cytokinesis.

O'Regan L, Fry AM. O'Regan L, et al. Mol Cell Biol. 2009 Jul;29(14):3975-90. doi: 10.1128/MCB.01867-08. Epub 2009 May 4. Mol Cell Biol. 2009. PMID: 19414596 Free PMC article.

5

An autoinhibitory tyrosine motif in the cell-cycle-regulated Nek7 kinase is released through binding of Nek9.

Richards MW, O'Regan L, Mas-Droux C, Blot JM, Cheung J, Hoelder S, Fry AM, Bayliss R. Richards MW, et al. Mol Cell. 2009 Nov 25;36(4):560-70. doi: 10.1016/j.molcel.2009.09.038. Mol Cell. 2009. PMID: 19941817 Free PMC article.

6

Cell cycle regulation by the NEK family of protein kinases.

Fry AM, O'Regan L, Sabir SR, Bayliss R. Fry AM, et al. J Cell Sci. 2012 Oct 1;125(Pt 19):4423-33. doi: 10.1242/jcs.111195. Epub 2012 Nov 6. J Cell Sci. 2012. PMID: 23132929 Free PMC article. Review.

7

Crystal structure of EML1 reveals the basis for Hsp90 dependence of oncogenic EML4-ALK by disruption of an atypical β-propeller domain.

Richards MW, Law EW, Rennalls LP, Busacca S, O'Regan L, Fry AM, Fennell DA, Bayliss R. Richards MW, et al. Proc Natl Acad Sci U S A. 2014 Apr 8;111(14):5195-200. doi: 10.1073/pnas.1322892111. Epub 2014 Mar 24. Proc Natl Acad Sci U S A. 2014. PMID: 24706829 Free PMC article.

8

Histone deacetylase (HDAC) 1 and 2 are essential for accurate cell division and the pluripotency of embryonic stem cells.

Jamaladdin S, Kelly RD, O'Regan L, Dovey OM, Hodson GE, Millard CJ, Portolano N, Fry AM, Schwabe JW, Cowley SM. Jamaladdin S, et al. Proc Natl Acad Sci U S A. 2014 Jul 8;111(27):9840-5. doi: 10.1073/pnas.1321330111. Epub 2014 Jun 23. Proc Natl Acad Sci U S A. 2014. PMID: 24958871 Free PMC article.

9

Microtubule association of EML proteins and the EML4-ALK variant 3 oncoprotein require an N-terminal trimerization domain.

Richards MW, O'Regan L, Roth D, Montgomery JM, Straube A, Fry AM, Bayliss R. Richards MW, et al. Biochem J. 2015 May 1;467(3):529-36. doi: 10.1042/BJ20150039. Biochem J. 2015. PMID: 25740311 Free article.

10

Hsp72 is targeted to the mitotic spindle by Nek6 to promote K-fiber assembly and mitotic progression.

O'Regan L, Sampson J, Richards MW, Knebel A, Roth D, Hood FE, Straube A, Royle SJ, Bayliss R, Fry AM. O'Regan L, et al. J Cell Biol. 2015 May 11;209(3):349-58. doi: 10.1083/jcb.201409151. Epub 2015 May 4. J Cell Biol. 2015. PMID: 25940345 Free PMC article.

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