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Page 1
De Novo Purine Metabolism is a Metabolic Vulnerability of Cancers with Low p16 Expression.
Tangudu NK, Buj R, Wang H, Wang J, Cole AR, Uboveja A, Fang R, Amalric A, Yang B, Chatoff A, Crispim CV, Sajjakulnukit P, Lyons MA, Cooper K, Hempel N, Lyssiotis CA, Chandran UR, Snyder NW, Aird KM. Tangudu NK, et al. Among authors: snyder nw. Cancer Res Commun. 2024 May 2;4(5):1174-1188. doi: 10.1158/2767-9764.CRC-23-0450. Cancer Res Commun. 2024. PMID: 38626341 Free PMC article.
The Glucose Transporter 5 Enhances CAR-T Cell Metabolic Function and Anti-tumour Durability.
Valentić B, Kelly A, Shestov AA, Gan Z, Shen F, Chatoff A, Jaccard A, Crispim CV, Scholler J, Heeke S, Snyder NW, Ghassemi S, Jones N, Gill S, O'Connor RS. Valentić B, et al. Among authors: snyder nw. Res Sq [Preprint]. 2024 May 7:rs.3.rs-4342820. doi: 10.21203/rs.3.rs-4342820/v1. Res Sq. 2024. PMID: 38766088 Free PMC article. Preprint.
Lysine catabolism reprograms tumour immunity through histone crotonylation.
Yuan H, Wu X, Wu Q, Chatoff A, Megill E, Gao J, Huang T, Duan T, Yang K, Jin C, Yuan F, Wang S, Zhao L, Zinn PO, Abdullah KG, Zhao Y, Snyder NW, Rich JN. Yuan H, et al. Among authors: snyder nw. Nature. 2023 May;617(7962):818-826. doi: 10.1038/s41586-023-06061-0. Epub 2023 May 17. Nature. 2023. PMID: 37198486 Free PMC article.
αKG-mediated carnitine synthesis promotes homologous recombination via histone acetylation.
Uboveja A, Huang Z, Buj R, Amalric A, Wang H, Tangudu NK, Cole AR, Megill E, Kantner D, Chatoff A, Ahmad H, Marcinkiewicz MM, Disharoon JA, Graff S, Dahl ES, Hempel N, Stallaert W, Sidoli S, Bitler BG, Long DT, Snyder NW, Aird KM. Uboveja A, et al. Among authors: snyder nw. bioRxiv [Preprint]. 2024 Feb 11:2024.02.06.578742. doi: 10.1101/2024.02.06.578742. bioRxiv. 2024. PMID: 38370789 Free PMC article. Preprint.
Brown fat ATP-citrate lyase links carbohydrate availability to thermogenesis and guards against metabolic stress.
Korobkina ED, Calejman CM, Haley JA, Kelly ME, Li H, Gaughan M, Chen Q, Pepper HL, Ahmad H, Boucher A, Fluharty SM, Lin TY, Lotun A, Peura J, Trefely S, Green CR, Vo P, Semenkovich CF, Pitarresi JR, Spinelli JB, Aydemir O, Metallo CM, Lynes MD, Jang C, Snyder NW, Wellen KE, Guertin DA. Korobkina ED, et al. Among authors: snyder nw. Nat Metab. 2024 Nov;6(11):2187-2202. doi: 10.1038/s42255-024-01143-3. Epub 2024 Oct 14. Nat Metab. 2024. PMID: 39402290
Lysine L-lactylation is the dominant lactylation isomer induced by glycolysis.
Zhang D, Gao J, Zhu Z, Mao Q, Xu Z, Singh PK, Rimayi CC, Moreno-Yruela C, Xu S, Li G, Sin YC, Chen Y, Olsen CA, Snyder NW, Dai L, Li L, Zhao Y. Zhang D, et al. Among authors: snyder nw. Nat Chem Biol. 2025 Jan;21(1):91-99. doi: 10.1038/s41589-024-01680-8. Epub 2024 Jul 19. Nat Chem Biol. 2025. PMID: 39030363 Free PMC article.
141 results