Zhuang XM - Search Results

1

Prediction of Human Pharmacokinetics of E0703, a Novel Radioprotective Agent, Using Physiologically Based Pharmacokinetic Modeling and an Interspecies Extrapolation Approach.

Ge YX, Zhang Z, Yan JY, Ma ZC, Wang YG, Xiao CR, Zhuang XM, Gao Y. Ge YX, et al. Among authors: zhuang xm. Int J Mol Sci. 2024 Mar 6;25(5):3047. doi: 10.3390/ijms25053047. Int J Mol Sci. 2024. PMID: 38474292 Free PMC article.

2

Characterization of preclinical in vitro and in vivo ADME properties and prediction of human PK using a physiologically based pharmacokinetic model for YQA-14, a new dopamine D3 receptor antagonist candidate for treatment of drug addiction.

Liu F, Zhuang X, Yang C, Li Z, Xiong S, Zhang Z, Li J, Lu C, Zhang Z. Liu F, et al. Biopharm Drug Dispos. 2014 Jul;35(5):296-307. doi: 10.1002/bdd.1897. Epub 2014 Apr 13. Biopharm Drug Dispos. 2014. PMID: 24647883

3

Prediction of Drug-Drug Interaction between Tacrolimus and Principal Ingredients of Wuzhi Capsule in Chinese Healthy Volunteers Using Physiologically-Based Pharmacokinetic Modelling.

Zhang H, Bu F, Li L, Jiao Z, Ma G, Cai W, Zhuang X, Lin HS, Shin JG, Xiang X. Zhang H, et al. Basic Clin Pharmacol Toxicol. 2018 Mar;122(3):331-340. doi: 10.1111/bcpt.12914. Epub 2017 Oct 25. Basic Clin Pharmacol Toxicol. 2018. PMID: 28945011 Free article.

4

Identification of human cytochrome P450 and UGT enzymes involved in the metabolism of ferulic acid, a major bioactive component in traditional Chinese medicines.

Zhuang XM, Chen L, Tan Y, Yang HY, Lu C, Gao Y, Li H. Zhuang XM, et al. Chin J Nat Med. 2017 Sep;15(9):695-702. doi: 10.1016/S1875-5364(17)30099-7. Chin J Nat Med. 2017. PMID: 28991531

5

Assessment and Confirmation of Species Difference in Nonlinear Pharmacokinetics of Atipamezole with Physiologically Based Pharmacokinetic Modeling.

Li Z, Gao Y, Yang C, Xiang Y, Zhang W, Zhang T, Su R, Lu C, Zhuang X. Li Z, et al. Drug Metab Dispos. 2020 Jan;48(1):41-51. doi: 10.1124/dmd.119.089151. Epub 2019 Nov 7. Drug Metab Dispos. 2020. PMID: 31699808

6

New insights into the vancomycin-induced nephrotoxicity using in vitro metabolomics combined with physiologically based pharmacokinetic modeling.

Du H, Li Z, Yang Y, Li X, Wei Y, Lin Y, Zhuang X. Du H, et al. J Appl Toxicol. 2020 Jul;40(7):897-907. doi: 10.1002/jat.3951. Epub 2020 Feb 20. J Appl Toxicol. 2020. PMID: 32079046

7

Examination of the Impact of CYP3A4/5 on Drug-Drug Interaction between Schizandrol A/Schizandrol B and Tacrolimus (FK-506): A Physiologically Based Pharmacokinetic Modeling Approach.

He Q, Bu F, Wang Q, Li M, Lin J, Tang Z, Mak WY, Zhuang X, Zhu X, Lin HS, Xiang X. He Q, et al. Int J Mol Sci. 2022 Apr 19;23(9):4485. doi: 10.3390/ijms23094485. Int J Mol Sci. 2022. PMID: 35562875 Free PMC article.

8

Translational pharmacokinetics of a novel bispecific antibody against Ebola virus (MBS77E) from animal to human by PBPK modeling & simulation.

Zhang W, Xiang Y, Wang L, Wang F, Li G, Zhuang X. Zhang W, et al. Int J Pharm. 2022 Oct 15;626:122160. doi: 10.1016/j.ijpharm.2022.122160. Epub 2022 Sep 9. Int J Pharm. 2022. PMID: 36089211 Free article.

9

Alternation of Organ-Specific Exposure in LPS-Induced Pneumonia Mice after the Inhalation of Tetrandrine Is Governed by Metabolizing Enzyme Suppression and Lysosomal Trapping.

Wang F, Jiang X, Yang Z, Fu S, Yao S, Wang L, Lv Y, Zhang W, Ding R, Zhuang X. Wang F, et al. Int J Mol Sci. 2022 Oct 26;23(21):12948. doi: 10.3390/ijms232112948. Int J Mol Sci. 2022. PMID: 36361734 Free PMC article.

10

Insights into Inhalation Drug Disposition: The Roles of Pulmonary Drug-Metabolizing Enzymes and Transporters.

Dong L, Zhuang X. Dong L, et al. Int J Mol Sci. 2024 Apr 25;25(9):4671. doi: 10.3390/ijms25094671. Int J Mol Sci. 2024. PMID: 38731891 Free PMC article. Review.

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