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Structure-Guided Design and Optimization of Covalent VHL-Targeted Sulfonyl Fluoride PROTACs.
J Med Chem. 2024 Mar 28;67(6):4641-4654. doi: 10.1021/acs.jmedchem.3c02123. Epub 2024 Mar 13.
J Med Chem. 2024.
PMID: 38478885
Free PMC article.
A covalent succinylcysteine-like intermediate in the enzyme-catalyzed transformation of maleate to fumarate by maleate isomerase.
Fisch F, Fleites CM, Delenne M, Baudendistel N, Hauer B, Turkenburg JP, Hart S, Bruce NC, Grogan G.
Fisch F, et al. Among authors: fleites cm.
J Am Chem Soc. 2010 Aug 25;132(33):11455-7. doi: 10.1021/ja1053576.
J Am Chem Soc. 2010.
PMID: 20677745
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