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Microglia depletion reduces human neuronal APOE4-related pathologies in a chimeric Alzheimer's disease model.
Rao A, Chen N, Kim MJ, Blumenfeld J, Yip O, Liang Z, Shostak D, Hao Y, Nelson MR, Koutsodendris N, Grone B, Ding L, Yoon SY, Arriola P, Zilberter M, Huang Y. Rao A, et al. Among authors: koutsodendris n. Cell Stem Cell. 2024 Oct 30:S1934-5909(24)00367-9. doi: 10.1016/j.stem.2024.10.005. Online ahead of print. Cell Stem Cell. 2024. PMID: 39500314 Free article.
APOE4/4 is linked to damaging lipid droplets in Alzheimer's disease microglia.
Haney MS, Pálovics R, Munson CN, Long C, Johansson PK, Yip O, Dong W, Rawat E, West E, Schlachetzki JCM, Tsai A, Guldner IH, Lamichhane BS, Smith A, Schaum N, Calcuttawala K, Shin A, Wang YH, Wang C, Koutsodendris N, Serrano GE, Beach TG, Reiman EM, Glass CK, Abu-Remaileh M, Enejder A, Huang Y, Wyss-Coray T. Haney MS, et al. Among authors: koutsodendris n. Nature. 2024 Apr;628(8006):154-161. doi: 10.1038/s41586-024-07185-7. Epub 2024 Mar 13. Nature. 2024. PMID: 38480892 Free PMC article.
Microglia Depletion Reduces Human Neuronal APOE4-Driven Pathologies in a Chimeric Alzheimer's Disease Model.
Rao A, Chen N, Kim MJ, Blumenfeld J, Yip O, Hao Y, Liang Z, Nelson MR, Koutsodendris N, Grone B, Ding L, Yoon SY, Arriola P, Huang Y. Rao A, et al. Among authors: koutsodendris n. bioRxiv [Preprint]. 2023 Nov 14:2023.11.10.566510. doi: 10.1101/2023.11.10.566510. bioRxiv. 2023. Update in: Cell Stem Cell. 2024 Oct 30:S1934-5909(24)00367-9. doi: 10.1016/j.stem.2024.10.005 PMID: 38014339 Free PMC article. Updated. Preprint.
The APOE-R136S mutation protects against APOE4-driven Tau pathology, neurodegeneration and neuroinflammation.
Nelson MR, Liu P, Agrawal A, Yip O, Blumenfeld J, Traglia M, Kim MJ, Koutsodendris N, Rao A, Grone B, Hao Y, Yoon SY, Xu Q, De Leon S, Choenyi T, Thomas R, Lopera F, Quiroz YT, Arboleda-Velasquez JF, Reiman EM, Mahley RW, Huang Y. Nelson MR, et al. Among authors: koutsodendris n. Nat Neurosci. 2023 Dec;26(12):2104-2121. doi: 10.1038/s41593-023-01480-8. Epub 2023 Nov 13. Nat Neurosci. 2023. PMID: 37957317 Free PMC article.
Neuronal APOE4-induced Early Hippocampal Network Hyperexcitability in Alzheimer's Disease Pathogenesis.
Tabuena DR, Jang SS, Grone B, Yip O, Aery Jones EA, Blumenfeld J, Liang Z, Koutsodendris N, Rao A, Ding L, Zhang AR, Hao Y, Xu Q, Yoon SY, Leon S, Huang Y, Zilberter M. Tabuena DR, et al. Among authors: koutsodendris n. bioRxiv [Preprint]. 2024 Jul 3:2023.08.28.555153. doi: 10.1101/2023.08.28.555153. bioRxiv. 2024. PMID: 37693533 Free PMC article. Preprint.
APOE4/4 is linked to damaging lipid droplets in Alzheimer's microglia.
Haney MS, Pálovics R, Munson CN, Long C, Johansson P, Yip O, Dong W, Rawat E, West E, Schlachetzki JC, Tsai A, Guldner IH, Lamichhane BS, Smith A, Schaum N, Calcuttawala K, Shin A, Wang YH, Wang C, Koutsodendris N, Serrano GE, Beach TG, Reiman EM, Glass CK, Abu-Remaileh M, Enejder A, Huang Y, Wyss-Coray T. Haney MS, et al. Among authors: koutsodendris n. bioRxiv [Preprint]. 2023 Jul 25:2023.07.21.549930. doi: 10.1101/2023.07.21.549930. bioRxiv. 2023. Update in: Nature. 2024 Apr;628(8006):154-161. doi: 10.1038/s41586-024-07185-7 PMID: 37546938 Free PMC article. Updated. Preprint.
Experimental and real-world evidence supporting the computational repurposing of bumetanide for APOE4-related Alzheimer's disease.
Taubes A, Nova P, Zalocusky KA, Kosti I, Bicak M, Zilberter MY, Hao Y, Yoon SY, Oskotsky T, Pineda S, Chen B, Jones EAA, Choudhary K, Grone B, Balestra ME, Chaudhry F, Paranjpe I, De Freitas J, Koutsodendris N, Chen N, Wang C, Chang W, An A, Glicksberg BS, Sirota M, Huang Y. Taubes A, et al. Among authors: koutsodendris n. Nat Aging. 2021 Oct;1(10):932-947. doi: 10.1038/s43587-021-00122-7. Epub 2021 Oct 11. Nat Aging. 2021. PMID: 36172600 Free PMC article.
15 results