Li Y - Search Results

1

Subtle Structural Changes across the Boundary between A_2AR/A_2BR Dual Antagonism and A_2BR Antagonism: A Novel Class of 2-Aminopyrimidine-Based Derivatives.

Wang H, Yang X, Li Y, Ze S, Feng B, Weng Y, Gao A, Song G, Liu M, Xie Q, Wang Y, Lu W. Wang H, et al. Among authors: li y. J Med Chem. 2024 Mar 28;67(6):5075-5092. doi: 10.1021/acs.jmedchem.4c00250. Epub 2024 Mar 14. J Med Chem. 2024. PMID: 38483150

2

Structure-Based Optimization of 3-Phenyl-N-(2-(3-phenylureido)ethyl)thiophene-2-sulfonamide Derivatives as Selective Mcl-1 Inhibitors.

Li Y, Fan W, Gong Q, Tian J, Zhou M, Li Q, Uwituze LB, Zhang Z, Hong R, Wang R. Li Y, et al. Among authors: li q. J Med Chem. 2021 Jul 22;64(14):10260-10285. doi: 10.1021/acs.jmedchem.1c00690. Epub 2021 Jul 6. J Med Chem. 2021. PMID: 34228434

3

PLANET: A Multi-objective Graph Neural Network Model for Protein-Ligand Binding Affinity Prediction.

Zhang X, Gao H, Wang H, Chen Z, Zhang Z, Chen X, Li Y, Qi Y, Wang R. Zhang X, et al. Among authors: li y. J Chem Inf Model. 2024 Apr 8;64(7):2205-2220. doi: 10.1021/acs.jcim.3c00253. Epub 2023 Jun 15. J Chem Inf Model. 2024. PMID: 37319418

4

Discovery of Biaryl Amide Derivatives as Potent, Selective, and Orally Bioavailable RORγt Agonists for Cancer Immunotherapy.

Lu L, Huang Y, Song M, Sun N, Xia L, Yu M, Zhao M, Qiu R, Chen JA, Zhao Y, Wang H, Guo H, Li Y, Zhu D, Wang Y, Xie Q. Lu L, et al. Among authors: li y. J Med Chem. 2023 Dec 14;66(23):16091-16108. doi: 10.1021/acs.jmedchem.3c01492. Epub 2023 Nov 20. J Med Chem. 2023. PMID: 37982494

5

B-cell lymphoma-2 family proteins in the crosshairs: Small molecule inhibitors and activators for cancer therapy.

Gong Q, Wang H, Zhou M, Zhou L, Wang R, Li Y. Gong Q, et al. Among authors: li y. Med Res Rev. 2024 Mar;44(2):707-737. doi: 10.1002/med.21999. Epub 2023 Nov 20. Med Res Rev. 2024. PMID: 37983840 Review.

6

Discovery of Phenylpyrazole Derivatives as a New Class of Selective Inhibitors of MCL-1 with Antitumor Activity.

Gong Q, Li C, Wang H, Cao J, Li Z, Zhou M, Li Y, Chu Y, Liu H, Wang R. Gong Q, et al. Among authors: li c, li y, li z. ACS Omega. 2024 Jun 13;9(25):27369-27396. doi: 10.1021/acsomega.4c02021. eCollection 2024 Jun 25. ACS Omega. 2024. PMID: 38947842 Free PMC article.

7

Synthesis and anti-tumor activities of N'-benzylidene-2-(4-oxothieno[2,3-d]pyrimidin-3(4H)-yl)acetohydrazone derivatives.

Lou J, Liu Z, Li Y, Zhou M, Zhang Z, Zheng S, Wang R, Li J. Lou J, et al. Among authors: li y, li j. Bioorg Med Chem Lett. 2011 Nov 15;21(22):6662-6. doi: 10.1016/j.bmcl.2011.09.061. Epub 2011 Sep 21. Bioorg Med Chem Lett. 2011. PMID: 21986587

8

Optimization of Beclin 1-Targeting Stapled Peptides by Staple Scanning Leads to Enhanced Antiproliferative Potency in Cancer Cells.

Yang Q, Qiu X, Zhang X, Yu Y, Li N, Wei X, Feng G, Li Y, Zhao Y, Wang R. Yang Q, et al. Among authors: li y, li n. J Med Chem. 2021 Sep 23;64(18):13475-13486. doi: 10.1021/acs.jmedchem.1c00870. Epub 2021 Sep 10. J Med Chem. 2021. PMID: 34506131

9

HydraMap v.2: Prediction of Hydration Sites and Desolvation Energy with Refined Statistical Potentials.

Li Y, Zhang Z, Wang R. Li Y, et al. J Chem Inf Model. 2023 Aug 14;63(15):4749-4761. doi: 10.1021/acs.jcim.3c00408. Epub 2023 Jul 11. J Chem Inf Model. 2023. PMID: 37433022

10

Fragment-Based Computational Method for Designing GPCR Ligands.

Li Y, Sun Y, Song Y, Dai D, Zhao Z, Zhang Q, Zhong W, Hu LA, Ma Y, Li X, Wang R. Li Y, et al. Among authors: li x. J Chem Inf Model. 2020 Sep 28;60(9):4339-4349. doi: 10.1021/acs.jcim.9b00699. Epub 2019 Nov 11. J Chem Inf Model. 2020. PMID: 31652060

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