Hu B - Search Results

1

Identification of a Novel Selective CDK9 Inhibitor for the Treatment of CRC: Design, Synthesis, and Biological Activity Evaluation.

Zhong Y, Xu J, Zhou R, Tang L, Ding S, Ren Z, Song N, Hu B, Yang H, Sun Y, Cheng M, Li J, Liu Y. Zhong Y, et al. Among authors: hu b. J Med Chem. 2024 Mar 28;67(6):4739-4756. doi: 10.1021/acs.jmedchem.3c02329. Epub 2024 Mar 15. J Med Chem. 2024. PMID: 38488882

2

Pyrrolo[2,1-c][1,4] benzodiazepine-3,11-diones protect SHSY-5Y cells from Cd-induced apoptosis involving suppression of endoplasmic reticulum stress.

Ma C, Du K, Zhao Y, Zhang L, Hu B, Cheng M. Ma C, et al. Among authors: hu b. Bioorg Med Chem. 2018 Oct 1;26(18):5151-5158. doi: 10.1016/j.bmc.2018.09.011. Epub 2018 Sep 11. Bioorg Med Chem. 2018. PMID: 30243792

3

Discovery of novel cathepsin inhibitors with potent anti-metastatic effects in breast cancer cells.

Yuan L, Sheng L, He W, Zou C, Hu B, Liu J, Ge W, Liu Y, Wang J, Ma E. Yuan L, et al. Among authors: hu b. Bioorg Chem. 2018 Dec;81:672-680. doi: 10.1016/j.bioorg.2018.09.029. Epub 2018 Sep 20. Bioorg Chem. 2018. PMID: 30253340

4

Computational investigation of the antagonism effect towards GluN2B-Containing NMDA receptor: Combined ligand-based and target-based approach.

Ma C, Hu B, Zhang L, Zhao Y, Wang M, Wang J, Cheng M. Ma C, et al. Among authors: hu b. J Mol Graph Model. 2019 Jan;86:95-105. doi: 10.1016/j.jmgm.2018.10.009. Epub 2018 Oct 10. J Mol Graph Model. 2019. PMID: 30343207

5

Computational insight into dengue virus NS2B-NS3 protease inhibition: A combined ligand- and structure-based approach.

Chen J, Jiang H, Li F, Hu B, Wang Y, Wang M, Wang J, Cheng M. Chen J, et al. Among authors: hu b. Comput Biol Chem. 2018 Dec;77:261-271. doi: 10.1016/j.compbiolchem.2018.09.010. Epub 2018 Sep 13. Comput Biol Chem. 2018. PMID: 30393100

6

Discovery of a novel cathepsin inhibitor with dual autophagy-inducing and metastasis-inhibiting effects on breast cancer cells.

Yuan L, Liu J, He W, Bao Y, Sheng L, Zou C, Hu B, Ge W, Liu Y, Wang J, Lin B, Li Y, Ma E. Yuan L, et al. Among authors: hu b. Bioorg Chem. 2019 Mar;84:239-253. doi: 10.1016/j.bioorg.2018.11.025. Epub 2018 Nov 22. Bioorg Chem. 2019. PMID: 30503850

7

Precise design of highly isoform-selective p21-activated kinase 4 inhibitors: computational insights into the selectivity mechanism through molecular dynamics simulation and binding free energy calculation.

Su Y, Song P, Wang H, Hu B, Wang J, Cheng MS. Su Y, et al. Among authors: hu b. J Biomol Struct Dyn. 2020 Aug;38(13):3825-3837. doi: 10.1080/07391102.2019.1664330. Epub 2019 Sep 15. J Biomol Struct Dyn. 2020. PMID: 31490101

8

Molecular dynamics simulation and QM/MM calculation reveal the selectivity mechanism of type I 1/2 kinase inhibitors: the effect of intramolecular H-bonds and conformational restriction for improved selectivity.

Wang H , Gao Z , Song P , Hu B , Wang J , Cheng M . Wang H , et al. Among authors: hu b. Phys Chem Chem Phys. 2019 Nov 7;21(43):24147-24164. doi: 10.1039/c9cp04353e. Phys Chem Chem Phys. 2019. PMID: 31657381

9

A novel cathepsin L inhibitor prevents the progression of idiopathic pulmonary fibrosis.

Yuan L, Zou C, Ge W, Liu Y, Hu B, Wang J, Lin B, Li Y, Ma E. Yuan L, et al. Among authors: hu b. Bioorg Chem. 2020 Jan;94:103417. doi: 10.1016/j.bioorg.2019.103417. Epub 2019 Nov 11. Bioorg Chem. 2020. PMID: 31744600

10

Computational investigation reveals Picrasidine C as selective PPARα lead: binding pattern, selectivity mechanism and ADME/tox profile.

Li F, Wang H, Wang Y, Feng S, Hu B, Zhang X, Wang J, Li W, Cheng M. Li F, et al. Among authors: hu b. J Biomol Struct Dyn. 2020 Nov;38(18):5401-5418. doi: 10.1080/07391102.2019.1699861. Epub 2019 Dec 12. J Biomol Struct Dyn. 2020. PMID: 31787028

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