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Page 1
Pan AMPK Activation Protects Tubules in Rat Ischemic Acute Kidney Injury.
Frikke-Schmidt H, Albarazanji K, Qi J, Frederick D, Steffen J, Kalyana-Sundaram S, Meng R, Devine ZH, Chen T, Li Q, Du F, Ho G, Liu J, Riley R, Gonzalez-Villalobos RA, Camacho RC, Nawrocki AR, Pryor M, Lee M, Wong V, Matico R, Diaz E, Krosky D, Wall M, Gao E, Shah AA, Leonard J, Erion M, Pocai A, Player MR. Frikke-Schmidt H, et al. Among authors: nawrocki ar. J Pharmacol Exp Ther. 2024 Jun 7:JPET-AR-2024-002120. doi: 10.1124/jpet.124.002120. Online ahead of print. J Pharmacol Exp Ther. 2024. PMID: 38849142 Free article.
Adipogenin Dictates Adipose Tissue Expansion by Facilitating the Assembly of a Dodecameric Seipin Complex.
Li C, Sun XN, Funcke JB, Vanharanta L, Joffin N, Li Y, Prasanna X, Paredes M, Joung C, Gordillo R, Vörös C, Kulig W, Straub L, Chen S, Velasco J, Cobb A, Padula D, Wang MY, Onodera T, Varlamov O, Li Y, Liu C, Nawrocki AR, Zhao S, Oh DY, Wang ZV, Goodman JM, Wynn RM, Vattulainen I, Han Y, Ikonen E, Scherer PE. Li C, et al. Among authors: nawrocki ar. bioRxiv [Preprint]. 2024 Jul 26:2024.07.25.605195. doi: 10.1101/2024.07.25.605195. bioRxiv. 2024. PMID: 39211078 Free PMC article. Preprint.
Discovery of MK-1462: GLP-1 and Glucagon Receptor Dual Agonist for the Treatment of Obesity and Diabetes.
Palani A, Nawrocki AR, Orvieto F, Bianchi E, Mandić E, Pessi A, Huang C, Deng Q, Toussaint N, Walsh E, Reddy V, Ashley E, He H, Mumick S, Hawes B, Marsh D, Erion M, Nargund R, Carrington PE. Palani A, et al. Among authors: nawrocki ar. ACS Med Chem Lett. 2022 Jul 21;13(8):1248-1254. doi: 10.1021/acsmedchemlett.2c00217. eCollection 2022 Aug 11. ACS Med Chem Lett. 2022. PMID: 35978682 Free PMC article.
The mitochondrial fission protein Drp1 in liver is required to mitigate NASH and prevents the activation of the mitochondrial ISR.
Steffen J, Ngo J, Wang SP, Williams K, Kramer HF, Ho G, Rodriguez C, Yekkala K, Amuzie C, Bialecki R, Norquay L, Nawrocki AR, Erion M, Pocai A, Shirihai OS, Liesa M. Steffen J, et al. Among authors: nawrocki ar. Mol Metab. 2022 Oct;64:101566. doi: 10.1016/j.molmet.2022.101566. Epub 2022 Aug 6. Mol Metab. 2022. PMID: 35940556 Free PMC article.
Pharmacological AMPK activation induces transcriptional responses congruent to exercise in skeletal and cardiac muscle, adipose tissues and liver.
Muise ES, Guan HP, Liu J, Nawrocki AR, Yang X, Wang C, Rodríguez CG, Zhou D, Gorski JN, Kurtz MM, Feng D, Leavitt KJ, Wei L, Wilkening RR, Apgar JM, Xu S, Lu K, Feng W, Li Y, He H, Previs SF, Shen X, van Heek M, Souza SC, Rosenbach MJ, Biftu T, Erion MD, Kelley DE, Kemp DM, Myers RW, Sebhat IK. Muise ES, et al. Among authors: nawrocki ar. PLoS One. 2019 Feb 27;14(2):e0211568. doi: 10.1371/journal.pone.0211568. eCollection 2019. PLoS One. 2019. PMID: 30811418 Free PMC article.
34 results