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Prolonged exposure to lung-derived cytokines is associated with activation of microglia in patients with COVID-19.
Grant RA, Poor TA, Sichizya L, Diaz E, Bailey JI, Soni S, Senkow KJ, Pérez-Leonor XG, Abdala-Valencia H, Lu Z, Donnelly HK, Simons LM, Ozer EA, Tighe RM, Lomasney JW, Wunderink RG, Singer BD, Misharin AV, Budinger GRS; Northwestern University Successful Clinical Response In Pneumonia Therapy (NU SCRIPT) Investigators. Grant RA, et al. Among authors: budinger grs. JCI Insight. 2024 Mar 19;9(8):e178859. doi: 10.1172/jci.insight.178859. JCI Insight. 2024. PMID: 38502186 Free PMC article.
Leptin promotes fibroproliferative acute respiratory distress syndrome by inhibiting peroxisome proliferator-activated receptor-γ.
Jain M, Budinger GR, Lo A, Urich D, Rivera SE, Ghosh AK, Gonzalez A, Chiarella SE, Marks K, Donnelly HK, Soberanes S, Varga J, Radigan KA, Chandel NS, Mutlu GM. Jain M, et al. Am J Respir Crit Care Med. 2011 Jun 1;183(11):1490-8. doi: 10.1164/rccm.201009-1409OC. Epub 2011 Feb 11. Am J Respir Crit Care Med. 2011. PMID: 21317313 Free PMC article.
Lung-specific loss of the laminin α3 subunit confers resistance to mechanical injury.
Urich D, Eisenberg JL, Hamill KJ, Takawira D, Chiarella SE, Soberanes S, Gonzalez A, Koentgen F, Manghi T, Hopkinson SB, Misharin AV, Perlman H, Mutlu GM, Budinger GR, Jones JC. Urich D, et al. J Cell Sci. 2011 Sep 1;124(Pt 17):2927-37. doi: 10.1242/jcs.080911. J Cell Sci. 2011. PMID: 21878500 Free PMC article.
The effect of rosuvastatin in a murine model of influenza A infection.
Radigan KA, Urich D, Misharin AV, Chiarella SE, Soberanes S, Gonzalez A, Perlman H, Wunderink RG, Budinger GR, Mutlu GM. Radigan KA, et al. PLoS One. 2012;7(4):e35788. doi: 10.1371/journal.pone.0035788. Epub 2012 Apr 20. PLoS One. 2012. PMID: 22536437 Free PMC article.
β₂-Adrenergic agonists augment air pollution-induced IL-6 release and thrombosis.
Chiarella SE, Soberanes S, Urich D, Morales-Nebreda L, Nigdelioglu R, Green D, Young JB, Gonzalez A, Rosario C, Misharin AV, Ghio AJ, Wunderink RG, Donnelly HK, Radigan KA, Perlman H, Chandel NS, Budinger GR, Mutlu GM. Chiarella SE, et al. J Clin Invest. 2014 Jul;124(7):2935-46. doi: 10.1172/JCI75157. Epub 2014 May 27. J Clin Invest. 2014. PMID: 24865431 Free PMC article.
Lung-specific loss of α3 laminin worsens bleomycin-induced pulmonary fibrosis.
Morales-Nebreda LI, Rogel MR, Eisenberg JL, Hamill KJ, Soberanes S, Nigdelioglu R, Chi M, Cho T, Radigan KA, Ridge KM, Misharin AV, Woychek A, Hopkinson S, Perlman H, Mutlu GM, Pardo A, Selman M, Jones JC, Budinger GR. Morales-Nebreda LI, et al. Am J Respir Cell Mol Biol. 2015 Apr;52(4):503-12. doi: 10.1165/rcmb.2014-0057OC. Am J Respir Cell Mol Biol. 2015. PMID: 25188360 Free PMC article.
Impaired clearance of influenza A virus in obese, leptin receptor deficient mice is independent of leptin signaling in the lung epithelium and macrophages.
Radigan KA, Morales-Nebreda L, Soberanes S, Nicholson T, Nigdelioglu R, Cho T, Chi M, Hamanaka RB, Misharin AV, Perlman H, Budinger GR, Mutlu GM. Radigan KA, et al. PLoS One. 2014 Sep 18;9(9):e108138. doi: 10.1371/journal.pone.0108138. eCollection 2014. PLoS One. 2014. PMID: 25232724 Free PMC article.
215 results