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Page 1
Design of amyloidogenic peptide traps.
Sahtoe DD, Andrzejewska EA, Han HL, Rennella E, Schneider MM, Meisl G, Ahlrichs M, Decarreau J, Nguyen H, Kang A, Levine P, Lamb M, Li X, Bera AK, Kay LE, Knowles TPJ, Baker D. Sahtoe DD, et al. Among authors: andrzejewska ea. Nat Chem Biol. 2024 Aug;20(8):981-990. doi: 10.1038/s41589-024-01578-5. Epub 2024 Mar 19. Nat Chem Biol. 2024. PMID: 38503834 Free PMC article.
Discovery of potent inhibitors of α-synuclein aggregation using structure-based iterative learning.
Horne RI, Andrzejewska EA, Alam P, Brotzakis ZF, Srivastava A, Aubert A, Nowinska M, Gregory RC, Staats R, Possenti A, Chia S, Sormanni P, Ghetti B, Caughey B, Knowles TPJ, Vendruscolo M. Horne RI, et al. Among authors: andrzejewska ea. Nat Chem Biol. 2024 May;20(5):634-645. doi: 10.1038/s41589-024-01580-x. Epub 2024 Apr 17. Nat Chem Biol. 2024. PMID: 38632492 Free PMC article.
Aβ Oligomer Dissociation Is Catalyzed by Fibril Surfaces.
Dear AJ, Thacker D, Wennmalm S, Ortigosa-Pascual L, Andrzejewska EA, Meisl G, Linse S, Knowles TPJ. Dear AJ, et al. Among authors: andrzejewska ea. ACS Chem Neurosci. 2024 Jun 5;15(11):2296-2307. doi: 10.1021/acschemneuro.4c00127. Epub 2024 May 24. ACS Chem Neurosci. 2024. PMID: 38785363 Free PMC article.
The role of shear forces in primary and secondary nucleation of amyloid fibrils.
Axell E, Hu J, Lindberg M, Dear AJ, Ortigosa-Pascual L, Andrzejewska EA, Šneiderienė G, Thacker D, Knowles TPJ, Sparr E, Linse S. Axell E, et al. Among authors: andrzejewska ea. Proc Natl Acad Sci U S A. 2024 Jun 18;121(25):e2322572121. doi: 10.1073/pnas.2322572121. Epub 2024 Jun 14. Proc Natl Acad Sci U S A. 2024. PMID: 38875148 Free PMC article.
α-Synuclein oligomers form by secondary nucleation.
Xu CK, Meisl G, Andrzejewska EA, Krainer G, Dear AJ, Castellana-Cruz M, Turi S, Edu IA, Vivacqua G, Jacquat RPB, Arter WE, Spillantini MG, Vendruscolo M, Linse S, Knowles TPJ. Xu CK, et al. Among authors: andrzejewska ea. Nat Commun. 2024 Aug 17;15(1):7083. doi: 10.1038/s41467-024-50692-4. Nat Commun. 2024. PMID: 39153989 Free PMC article.
Single-molecule digital sizing of proteins in solution.
Krainer G, Jacquat RPB, Schneider MM, Welsh TJ, Fan J, Peter QAE, Andrzejewska EA, Šneiderienė G, Czekalska MA, Ausserwoeger H, Chai L, Arter WE, Saar KL, Herling TW, Franzmann TM, Kosmoliaptsis V, Alberti S, Hartl FU, Lee SF, Knowles TPJ. Krainer G, et al. Among authors: andrzejewska ea. Nat Commun. 2024 Sep 4;15(1):7740. doi: 10.1038/s41467-024-50825-9. Nat Commun. 2024. PMID: 39231922 Free PMC article.