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scDrugPrio: a framework for the analysis of single-cell transcriptomics to address multiple problems in precision medicine in immune-mediated inflammatory diseases.
Schäfer S, Smelik M, Sysoev O, Zhao Y, Eklund D, Lilja S, Gustafsson M, Heyn H, Julia A, Kovács IA, Loscalzo J, Marsal S, Zhang H, Li X, Gawel D, Wang H, Benson M. Schäfer S, et al. Among authors: zhang h. Genome Med. 2024 Mar 20;16(1):42. doi: 10.1186/s13073-024-01314-7. Genome Med. 2024. PMID: 38509600 Free PMC article.
A validated single-cell-based strategy to identify diagnostic and therapeutic targets in complex diseases.
Gawel DR, Serra-Musach J, Lilja S, Aagesen J, Arenas A, Asking B, Bengnér M, Björkander J, Biggs S, Ernerudh J, Hjortswang H, Karlsson JE, Köpsen M, Lee EJ, Lentini A, Li X, Magnusson M, Martínez-Enguita D, Matussek A, Nestor CE, Schäfer S, Seifert O, Sonmez C, Stjernman H, Tjärnberg A, Wu S, Åkesson K, Shalek AK, Stenmarker M, Zhang H, Gustafsson M, Benson M. Gawel DR, et al. Among authors: zhang h. Genome Med. 2019 Jul 30;11(1):47. doi: 10.1186/s13073-019-0657-3. Genome Med. 2019. PMID: 31358043 Free PMC article.
Digital twins to personalize medicine.
Björnsson B, Borrebaeck C, Elander N, Gasslander T, Gawel DR, Gustafsson M, Jörnsten R, Lee EJ, Li X, Lilja S, Martínez-Enguita D, Matussek A, Sandström P, Schäfer S, Stenmarker M, Sun XF, Sysoev O, Zhang H, Benson M; Swedish Digital Twin Consortium. Björnsson B, et al. Among authors: zhang h. Genome Med. 2019 Dec 31;12(1):4. doi: 10.1186/s13073-019-0701-3. Genome Med. 2019. PMID: 31892363 Free PMC article.
Multi-organ single-cell analysis reveals an on/off switch system with potential for personalized treatment of immunological diseases.
Lilja S, Li X, Smelik M, Lee EJ, Loscalzo J, Marthanda PB, Hu L, Magnusson M, Sysoev O, Zhang H, Zhao Y, Sjöwall C, Gawel D, Wang H, Benson M. Lilja S, et al. Among authors: zhang h. Cell Rep Med. 2023 Mar 21;4(3):100956. doi: 10.1016/j.xcrm.2023.100956. Epub 2023 Feb 28. Cell Rep Med. 2023. PMID: 36858042 Free PMC article.
scDrugPrio: A framework for the analysis of single-cell transcriptomics to address multiple problems in precision medicine in immune-mediated inflammatory diseases.
Schäfer S, Smelik M, Sysoev O, Zhao Y, Eklund D, Lilja S, Gustafsson M, Heyn H, Julia A, Kovács IA, Loscalzo J, Marsal S, Zhang H, Li X, Gawel D, Wang H, Benson M. Schäfer S, et al. Among authors: zhang h. bioRxiv [Preprint]. 2023 Nov 13:2023.11.08.566249. doi: 10.1101/2023.11.08.566249. bioRxiv. 2023. Update in: Genome Med. 2024 Mar 20;16(1):42. doi: 10.1186/s13073-024-01314-7 PMID: 38014022 Free PMC article. Updated. Preprint.
Integrated genomic and prospective clinical studies show the importance of modular pleiotropy for disease susceptibility, diagnosis and treatment.
Gustafsson M, Edström M, Gawel D, Nestor CE, Wang H, Zhang H, Barrenäs F, Tojo J, Kockum I, Olsson T, Serra-Musach J, Bonifaci N, Pujana MA, Ernerudh J, Benson M. Gustafsson M, et al. Among authors: zhang h. Genome Med. 2014 Feb 26;6(2):17. doi: 10.1186/gm534. eCollection 2014. Genome Med. 2014. PMID: 24571673 Free PMC article.
Correction to: A validated single-cell-based strategy to identify diagnostic and therapeutic targets in complex diseases.
Gawel DR, Serra-Musach J, Lilja S, Aagesen J, Arenas A, Asking B, Bengnér M, Björkander J, Biggs S, Ernerudh J, Hjortswang H, Karlsson JE, Köpsen M, Lee EJ, Lentini A, Li X, Magnusson M, Martínez-Enguita D, Matussek A, Nestor CE, Schäfer S, Seifert O, Sonmez C, Stjernman H, Tjärnberg A, Wu S, Åkesson K, Shalek AK, Stenmarker M, Zhang H, Gustafsson M, Benson M. Gawel DR, et al. Among authors: zhang h. Genome Med. 2020 Apr 28;12(1):37. doi: 10.1186/s13073-020-00732-7. Genome Med. 2020. PMID: 32345376 Free PMC article.
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