Bauer MR - Search Results

1

Optimization of Potent Ligands for the E3 Ligase DCAF15 and Evaluation of Their Use in Heterobifunctional Degraders.

Lucas SCC, Ahmed A, Ashraf SN, Argyrou A, Bauer MR, De Donatis GM, Demanze S, Eisele F, Fusani L, Hock A, Kadamur G, Li S, Macmillan-Jones A, Michaelides IN, Phillips C, Rehnström M, Richter M, Rodrigo-Brenni MC, Shilliday F, Wang P, Storer RI. Lucas SCC, et al. Among authors: bauer mr. J Med Chem. 2024 Apr 11;67(7):5538-5566. doi: 10.1021/acs.jmedchem.3c02136. Epub 2024 Mar 21. J Med Chem. 2024. PMID: 38513086

2

Design and Evaluation of a Low Hydrogen Bond Donor Count Fragment Screening Set to Aid Hit Generation of PROTACs Intended for Oral Delivery.

Whitehurst BC, Bauer MR, Edfeldt F, Gunnarsson A, Margreitter C, Rawlins PB, Storer RI. Whitehurst BC, et al. Among authors: bauer mr. J Med Chem. 2023 Jun 8;66(11):7594-7604. doi: 10.1021/acs.jmedchem.3c00493. Epub 2023 May 24. J Med Chem. 2023. PMID: 37224440

3

A structure-guided molecular chaperone approach for restoring the transcriptional activity of the p53 cancer mutant Y220C.

Bauer MR, Jones RN, Tareque RK, Springett B, Dingler FA, Verduci L, Patel KJ, Fersht AR, Joerger AC, Spencer J. Bauer MR, et al. Future Med Chem. 2019 Oct;11(19):2491-2504. doi: 10.4155/fmc-2019-0181. Future Med Chem. 2019. PMID: 31633398 Free PMC article.

4

Aminobenzothiazole derivatives stabilize the thermolabile p53 cancer mutant Y220C and show anticancer activity in p53-Y220C cell lines.

Baud MGJ, Bauer MR, Verduci L, Dingler FA, Patel KJ, Horil Roy D, Joerger AC, Fersht AR. Baud MGJ, et al. Among authors: bauer mr. Eur J Med Chem. 2018 May 25;152:101-114. doi: 10.1016/j.ejmech.2018.04.035. Epub 2018 Apr 21. Eur J Med Chem. 2018. PMID: 29702446 Free PMC article.

5

Electrostatic Complementarity as a Fast and Effective Tool to Optimize Binding and Selectivity of Protein-Ligand Complexes.

Bauer MR, Mackey MD. Bauer MR, et al. J Med Chem. 2019 Mar 28;62(6):3036-3050. doi: 10.1021/acs.jmedchem.8b01925. Epub 2019 Mar 13. J Med Chem. 2019. PMID: 30807144

6

Synthesis and molecular modeling of novel tetrahydro-β-carboline derivatives with phosphodiesterase 5 inhibitory and anticancer properties.

Mohamed HA, Girgis NM, Wilcken R, Bauer MR, Tinsley HN, Gary BD, Piazza GA, Boeckler FM, Abadi AH. Mohamed HA, et al. Among authors: bauer mr. J Med Chem. 2011 Jan 27;54(2):495-509. doi: 10.1021/jm100842v. Epub 2010 Dec 28. J Med Chem. 2011. PMID: 21189023 Free PMC article.

7

Supporting SARS-CoV-2 Papain-Like Protease Drug Discovery: In silico Methods and Benchmarking.

Ibrahim TM, Ismail MI, Bauer MR, Bekhit AA, Boeckler FM. Ibrahim TM, et al. Among authors: bauer mr. Front Chem. 2020 Nov 5;8:592289. doi: 10.3389/fchem.2020.592289. eCollection 2020. Front Chem. 2020. PMID: 33251185 Free PMC article.

8

The curcumin analog HO-3867 selectively kills cancer cells by converting mutant p53 protein to transcriptionally active wildtype p53.

Madan E, Parker TM, Bauer MR, Dhiman A, Pelham CJ, Nagane M, Kuppusamy ML, Holmes M, Holmes TR, Shaik K, Shee K, Kiparoidze S, Smith SD, Park YA, Gomm JJ, Jones LJ, Tomás AR, Cunha AC, Selvendiran K, Hansen LA, Fersht AR, Hideg K, Gogna R, Kuppusamy P. Madan E, et al. Among authors: bauer mr. J Biol Chem. 2018 Mar 23;293(12):4262-4276. doi: 10.1074/jbc.RA117.000950. Epub 2018 Jan 30. J Biol Chem. 2018. PMID: 29382728 Free PMC article.

9

Thiazole-based IL-17 inhibitors discovered by scaffold morphing.

Velcicky J, Ngo E, Bauer MR, Meyer A, Schlapbach A, Racine S, Orain D, Pflieger D, Teixeira-Fouchard S, Dubois C, Goetz A, Steiner R, Palmieri M, Bussenault A, Stringer R, Larger P, Riek S, Schmutz P, Lehmann S, Scheufler C, Rondeau JM, Burkhart C, Knoepfel T, Gommermann N. Velcicky J, et al. Among authors: bauer mr. ChemMedChem. 2024 Dec 23:e202400851. doi: 10.1002/cmdc.202400851. Online ahead of print. ChemMedChem. 2024. PMID: 39715021

10

Dorsomedial striatal AMPA receptor antagonism increases alcohol binge drinking in selectively bred crossed high alcohol preferring mice.

Bauer MR, McVey MM, Zhang Y, Boehm SL 2nd. Bauer MR, et al. Eur J Neurosci. 2024 Nov;60(9):6300-6311. doi: 10.1111/ejn.16555. Epub 2024 Oct 2. Eur J Neurosci. 2024. PMID: 39358829

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