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Improvement of high-density lipoprotein atheroprotective properties in patients with systemic lupus erythematosus after belimumab treatment.
Dedemadi AG, Gkolfinopoulou C, Nikoleri D, Nikoloudaki M, Ruhanen H, Holopainen M, Kakela R, Christopoulou G, Bournazos S, Constantoulakis P, Sidiropoulos P, Bertsias G, Chroni A. Dedemadi AG, et al. Among authors: holopainen m. Rheumatology (Oxford). 2024 Mar 21:keae192. doi: 10.1093/rheumatology/keae192. Online ahead of print. Rheumatology (Oxford). 2024. PMID: 38514392
Mesenchymal Stromal Cells and Their Extracellular Vesicles Enhance the Anti-Inflammatory Phenotype of Regulatory Macrophages by Downregulating the Production of Interleukin (IL)-23 and IL-22.
Hyvärinen K, Holopainen M, Skirdenko V, Ruhanen H, Lehenkari P, Korhonen M, Käkelä R, Laitinen S, Kerkelä E. Hyvärinen K, et al. Among authors: holopainen m. Front Immunol. 2018 Apr 12;9:771. doi: 10.3389/fimmu.2018.00771. eCollection 2018. Front Immunol. 2018. PMID: 29706969 Free PMC article.
Lipid mediators in platelet concentrate and extracellular vesicles: Molecular mechanisms from membrane glycerophospholipids to bioactive molecules.
Valkonen S, Holopainen M, Colas RA, Impola U, Dalli J, Käkelä R, Siljander PR, Laitinen S. Valkonen S, et al. Among authors: holopainen m. Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Aug;1864(8):1168-1182. doi: 10.1016/j.bbalip.2019.03.011. Epub 2019 Apr 10. Biochim Biophys Acta Mol Cell Biol Lipids. 2019. PMID: 30980920
Vulnerability of invasive glioblastoma cells to lysosomal membrane destabilization.
Le Joncour V, Filppu P, Hyvönen M, Holopainen M, Turunen SP, Sihto H, Burghardt I, Joensuu H, Tynninen O, Jääskeläinen J, Weller M, Lehti K, Käkelä R, Laakkonen P. Le Joncour V, et al. Among authors: holopainen m. EMBO Mol Med. 2019 Jun;11(6):e9034. doi: 10.15252/emmm.201809034. EMBO Mol Med. 2019. PMID: 31068339 Free PMC article.
Polyunsaturated fatty acids modify the extracellular vesicle membranes and increase the production of proresolving lipid mediators of human mesenchymal stromal cells.
Holopainen M, Colas RA, Valkonen S, Tigistu-Sahle F, Hyvärinen K, Mazzacuva F, Lehenkari P, Käkelä R, Dalli J, Kerkelä E, Laitinen S. Holopainen M, et al. Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Oct;1864(10):1350-1362. doi: 10.1016/j.bbalip.2019.06.010. Epub 2019 Jun 15. Biochim Biophys Acta Mol Cell Biol Lipids. 2019. PMID: 31207356
Repetitive amiodarone administration causes liver damage via adipose tissue ER stress-dependent lipolysis, leading to hepatotoxic free fatty acid accumulation.
Hubel E, Fishman S, Holopainen M, Käkelä R, Shaffer O, Houri I, Zvibel I, Shibolet O. Hubel E, et al. Among authors: holopainen m. Am J Physiol Gastrointest Liver Physiol. 2021 Sep 1;321(3):G298-G307. doi: 10.1152/ajpgi.00458.2020. Epub 2021 Jul 14. Am J Physiol Gastrointest Liver Physiol. 2021. PMID: 34259586 Free article.
Lipidomic changes of LDL after consumption of Camelina sativa oil, fatty fish and lean fish in subjects with impaired glucose metabolism-A randomized controlled trial.
Erkkilä AT, Manninen S, Fredrikson L, Bhalke M, Holopainen M, Ruuth M, Lankinen M, Käkelä R, Öörni K, Schwab US. Erkkilä AT, et al. Among authors: holopainen m. J Clin Lipidol. 2021 Sep-Oct;15(5):743-751. doi: 10.1016/j.jacl.2021.08.060. Epub 2021 Sep 7. J Clin Lipidol. 2021. PMID: 34548243 Free article. Clinical Trial.
Low-density lipoprotein particles carrying proinflammatory proteins with altered aggregation pattern detected in COVID-19 patients 3 months after hospitalization.
Ueland T, Äikäs LAO, Dahl TB, Gregersen I, Olsen MB, Michelsen A, Schanke Y, Holopainen M, Ruhanen H, Singh S; NOR-SOLIDARITY Consortium; Tveita AA, Finbråten AK, Heggelund L, Trøseid M, Dyrhol-Riise AM, Nyman TA, Holven KB, Öörni K, Aukrust P, Halvorsen B. Ueland T, et al. Among authors: holopainen m. J Infect. 2023 May;86(5):489-492. doi: 10.1016/j.jinf.2023.02.024. Epub 2023 Feb 21. J Infect. 2023. PMID: 36822413 Free PMC article. No abstract available.
33 results