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Altered PBP4 and GdpP functions synergistically mediate MRSA-like high-level, broad-spectrum β-lactam resistance in Staphylococcus aureus.
Lai LY, Satishkumar N, Cardozo S, Hemmadi V, Marques LB, Huang L, Filipe SR, Pinho MG, Chambers HF, Chatterjee SS. Lai LY, et al. Among authors: satishkumar n. bioRxiv [Preprint]. 2023 Oct 27:2023.10.26.564222. doi: 10.1101/2023.10.26.564222. bioRxiv. 2023. Update in: mBio. 2024 May 8;15(5):e0288923. doi: 10.1128/mbio.02889-23 PMID: 37961375 Free PMC article. Updated. Preprint.
Structural basis of broad-spectrum β-lactam resistance in Staphylococcus aureus.
Alexander JAN, Worrall LJ, Hu J, Vuckovic M, Satishkumar N, Poon R, Sobhanifar S, Rosell FI, Jenkins J, Chiang D, Mosimann WA, Chambers HF, Paetzel M, Chatterjee SS, Strynadka NCJ. Alexander JAN, et al. Among authors: satishkumar n. Nature. 2023 Jan;613(7943):375-382. doi: 10.1038/s41586-022-05583-3. Epub 2023 Jan 4. Nature. 2023. PMID: 36599987 Free PMC article.
Loss of GdpP Function in Staphylococcus aureus Leads to β-Lactam Tolerance and Enhanced Evolution of β-Lactam Resistance.
Poon R, Basuino L, Satishkumar N, Chatterjee A, Mukkayyan N, Buggeln E, Huang L, Nair V, Argudín MA, Datta SK, Chambers HF, Chatterjee SS. Poon R, et al. Among authors: satishkumar n. Antimicrob Agents Chemother. 2022 Feb 15;66(2):e0143121. doi: 10.1128/AAC.01431-21. Epub 2021 Nov 29. Antimicrob Agents Chemother. 2022. PMID: 34843389 Free PMC article.