Jun J - Search Results

1

Targeting the CSF-1/CSF-1R Axis: Exploring the Potential of CSF1R Inhibitors in Neurodegenerative Diseases.

Baek J, Jun J, Kim H, Bae H, Park H, Cho H, Han S, Shin HC, Hah JM. Baek J, et al. Among authors: jun j. J Med Chem. 2024 Apr 11;67(7):5699-5720. doi: 10.1021/acs.jmedchem.3c02366. Epub 2024 Mar 26. J Med Chem. 2024. PMID: 38530425

2

Design and Synthesis of a Novel PLK1 Inhibitor Scaffold Using a Hybridized 3D-QSAR Model.

Oh Y, Jung H, Kim H, Baek J, Jun J, Cho H, Im D, Hah JM. Oh Y, et al. Among authors: jun j. Int J Mol Sci. 2021 Apr 8;22(8):3865. doi: 10.3390/ijms22083865. Int J Mol Sci. 2021. PMID: 33917995 Free PMC article.

3

Discovery of a Potent and Selective JNK3 Inhibitor with Neuroprotective Effect Against Amyloid β-Induced Neurotoxicity in Primary Rat Neurons.

Jun J, Baek J, Yang S, Moon H, Kim H, Cho H, Hah JM. Jun J, et al. Int J Mol Sci. 2021 Oct 14;22(20):11084. doi: 10.3390/ijms222011084. Int J Mol Sci. 2021. PMID: 34681742 Free PMC article.

4

Rational design and synthesis of 2-(1H-indazol-6-yl)-1H-benzo[d]imidazole derivatives as inhibitors targeting FMS-like tyrosine kinase 3 (FLT3) and its mutants.

Im D, Jun J, Baek J, Kim H, Kang D, Bae H, Cho H, Hah JM. Im D, et al. Among authors: jun j. J Enzyme Inhib Med Chem. 2022 Dec;37(1):472-486. doi: 10.1080/14756366.2021.2020772. J Enzyme Inhib Med Chem. 2022. PMID: 35067150 Free PMC article.

5

Discovery of novel imidazole chemotypes as isoform-selective JNK3 inhibitors for the treatment of Alzheimer's disease.

Jun J, Yang S, Lee J, Moon H, Kim J, Jung H, Im D, Oh Y, Jang M, Cho H, Baek J, Kim H, Kang D, Bae H, Tak C, Hwang K, Kwon H, Kim H, Hah JM. Jun J, et al. Eur J Med Chem. 2023 Jan 5;245(Pt 1):114894. doi: 10.1016/j.ejmech.2022.114894. Epub 2022 Nov 2. Eur J Med Chem. 2023. PMID: 36343411

6

Novel 1,4,5,6-tetrahydrocyclopenta[d]imidazole-5-carboxamide-based JNK3 inhibitors: Design, synthesis, molecular docking, and therapeutic potential in neurodegenerative diseases.

Jun J, Baek J, Kang D, Moon H, Kim H, Cho H, Hah JM. Jun J, et al. Eur J Med Chem. 2023 Jan 5;245(Pt 1):114917. doi: 10.1016/j.ejmech.2022.114917. Epub 2022 Nov 10. Eur J Med Chem. 2023. PMID: 36395646

7

Carbamate JNK3 Inhibitors Show Promise as Effective Treatments for Alzheimer's Disease: In Vivo Studies on Mouse Models.

Jun J, Moon H, Yang S, Lee J, Baek J, Kim H, Cho H, Hwang K, Ahn S, Kim Y, Kim G, Kim H, Kwon H, Hah JM. Jun J, et al. J Med Chem. 2023 May 11;66(9):6372-6390. doi: 10.1021/acs.jmedchem.3c00393. Epub 2023 Apr 24. J Med Chem. 2023. PMID: 37094094

8

Discovery of N-(5-amido-2-methylphenyl)-5-methylisoxazole-3-carboxamide as dual CSF-1R/c-Kit Inhibitors with improved stability and BBB permeability.

Baek J, Kim H, Jun J, Kang D, Bae H, Cho H, Hah JM. Baek J, et al. Among authors: jun j. Eur J Med Chem. 2024 Mar 15;268:116253. doi: 10.1016/j.ejmech.2024.116253. Epub 2024 Feb 20. Eur J Med Chem. 2024. PMID: 38401188

9

Gaining Insights into Key Structural Hotspots within the Allosteric Binding Pockets of Protein Kinases.

Bhujbal SP, Jun J, Park H, Moon J, Min K, Hah JM. Bhujbal SP, et al. Among authors: jun j. Int J Mol Sci. 2024 Apr 26;25(9):4725. doi: 10.3390/ijms25094725. Int J Mol Sci. 2024. PMID: 38731943 Free PMC article. Review.

10

Targeting JNK3 for Alzheimer's disease: Design and synthesis of novel inhibitors with aryl group diversity utilizing wide pocket.

Kim H, Park H, Jun J, Moon J, Oh J, Bhujbal SP, Hah JM. Kim H, et al. Among authors: jun j. Eur J Med Chem. 2025 Jan 3;285:117209. doi: 10.1016/j.ejmech.2024.117209. Online ahead of print. Eur J Med Chem. 2025. PMID: 39788062

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