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The GTPase activating protein Gyp7 regulates Rab7/Ypt7 activity on late endosomes.
Füllbrunn N, Nicastro R, Mari M, Griffith J, Herrmann E, Rasche R, Borchers AC, Auffarth K, Kümmel D, Reggiori F, De Virgilio C, Langemeyer L, Ungermann C. Füllbrunn N, et al. Among authors: nicastro r. J Cell Biol. 2024 Jun 3;223(6):e202305038. doi: 10.1083/jcb.202305038. Epub 2024 Mar 27. J Cell Biol. 2024. PMID: 38536036 Free PMC article.
The Architecture of the Rag GTPase Signaling Network.
Nicastro R, Sardu A, Panchaud N, De Virgilio C. Nicastro R, et al. Biomolecules. 2017 Jun 30;7(3):48. doi: 10.3390/biom7030048. Biomolecules. 2017. PMID: 28788436 Free PMC article. Review.
TORC1 Determines Fab1 Lipid Kinase Function at Signaling Endosomes and Vacuoles.
Chen Z, Malia PC, Hatakeyama R, Nicastro R, Hu Z, Péli-Gulli MP, Gao J, Nishimura T, Eskes E, Stefan CJ, Winderickx J, Dengjel J, De Virgilio C, Ungermann C. Chen Z, et al. Among authors: nicastro r. Curr Biol. 2021 Jan 25;31(2):297-309.e8. doi: 10.1016/j.cub.2020.10.026. Epub 2020 Nov 5. Curr Biol. 2021. PMID: 33157024 Free article.
Indole-3-acetic acid is a physiological inhibitor of TORC1 in yeast.
Nicastro R, Raucci S, Michel AH, Stumpe M, Garcia Osuna GM, Jaquenoud M, Kornmann B, De Virgilio C. Nicastro R, et al. PLoS Genet. 2021 Mar 9;17(3):e1009414. doi: 10.1371/journal.pgen.1009414. eCollection 2021 Mar. PLoS Genet. 2021. PMID: 33690632 Free PMC article.
Snf1/AMPK fine-tunes TORC1 signaling in response to glucose starvation.
Caligaris M, Nicastro R, Hu Z, Tripodi F, Hummel JE, Pillet B, Deprez MA, Winderickx J, Rospert S, Coccetti P, Dengjel J, De Virgilio C. Caligaris M, et al. Among authors: nicastro r. Elife. 2023 Feb 7;12:e84319. doi: 10.7554/eLife.84319. Elife. 2023. PMID: 36749016 Free PMC article.
Malonyl-CoA is a conserved endogenous ATP-competitive mTORC1 inhibitor.
Nicastro R, Brohée L, Alba J, Nüchel J, Figlia G, Kipschull S, Gollwitzer P, Romero-Pozuelo J, Fernandes SA, Lamprakis A, Vanni S, Teleman AA, De Virgilio C, Demetriades C. Nicastro R, et al. Nat Cell Biol. 2023 Sep;25(9):1303-1318. doi: 10.1038/s41556-023-01198-6. Epub 2023 Aug 10. Nat Cell Biol. 2023. PMID: 37563253 Free PMC article.
75 results