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Iron associated lipid peroxidation in Alzheimers disease is increased in lipid rafts with decreased ferroptosis suppressors, tested by chelation in mice.
Thorwald M, Godoy-Lugo JA, Garcia G, Silva J, Kim M, Christensen A, Mack WJ, Head E, O'Day PA, Benayoun BA, Morgan TE, Pike CJ, Higuchi-Sanabria R, Forman HJ, Finch CE. Thorwald M, et al. Among authors: head e. bioRxiv [Preprint]. 2024 Jun 13:2023.03.28.534324. doi: 10.1101/2023.03.28.534324. bioRxiv. 2024. PMID: 37034750 Free PMC article. Preprint.
Cerebrovascular disease is associated with Alzheimer's plasma biomarker concentrations in adults with Down syndrome.
Edwards NC, Lao PJ, Alshikho MJ, Ericsson OM, Rizvi B, Petersen ME, O'Bryant S, Aguilar LF, Simoes S, Mapstone M, Tudorascu DL, Janelidze S, Hansson O, Handen BL, Christian BT, Lee JH, Lai F, Rosas HD, Zaman S, Lott IT, Yassa MA; Alzheimer’s Biomarkers Consortium–Down Syndrome (ABC-DS) Investigators; Gutierrez J, Wilcock DM, Head E, Brickman AM. Edwards NC, et al. Among authors: head e. Brain Commun. 2024 Sep 25;6(5):fcae331. doi: 10.1093/braincomms/fcae331. eCollection 2024. Brain Commun. 2024. PMID: 39403075 Free PMC article.
Spatial and single-nucleus transcriptomic analysis of genetic and sporadic forms of Alzheimer's disease.
Miyoshi E, Morabito S, Henningfield CM, Das S, Rahimzadeh N, Shabestari SK, Michael N, Emerson N, Reese F, Shi Z, Cao Z, Srinivasan SS, Scarfone VM, Arreola MA, Lu J, Wright S, Silva J, Leavy K, Lott IT, Doran E, Yong WH, Shahin S, Perez-Rosendahl M; Alzheimer’s Biomarkers Consortium–Down Syndrome (ABC–DS); Head E, Green KN, Swarup V. Miyoshi E, et al. Among authors: head e. Nat Genet. 2024 Dec;56(12):2704-2717. doi: 10.1038/s41588-024-01961-x. Epub 2024 Nov 22. Nat Genet. 2024. PMID: 39578645 Free PMC article.
[No title available]
[No authors listed] [No authors listed] PMID: 39751584
The effects of mosaicism on biological and clinical markers of Alzheimer's disease in adults with Down syndrome.
Xicota L, Dang LT, Lee A, Krinsky-McHale S, Pang D, Melilli L, O'Bryant S, Henson RL, Laymon C, Lai F, Rosas HD, Ances B, Lott I, Hom C, Christian B, Hartley S, Zaman S, Head E, Mapstone M, Jin Z, Silverman W, Schupf N, Handen B, Lee JH; Alzheimer's Biomarker Consortium – Down Syndrome (ABC-DS). Xicota L, et al. Among authors: head e. EBioMedicine. 2024 Dec;110:105433. doi: 10.1016/j.ebiom.2024.105433. Epub 2024 Nov 4. EBioMedicine. 2024. PMID: 39500037 Free PMC article.
Timeline to symptomatic Alzheimer's disease in people with Down syndrome as assessed by amyloid-PET and tau-PET: a longitudinal cohort study.
Schworer EK, Zammit MD, Wang J, Handen BL, Betthauser T, Laymon CM, Tudorascu DL, Cohen AD, Zaman SH, Ances BM, Mapstone M, Head E, Christian BT, Hartley SL; Alzheimer's Biomarker Consortium–Down Syndrome (ABC–DS). Schworer EK, et al. Among authors: head e. Lancet Neurol. 2024 Dec;23(12):1214-1224. doi: 10.1016/S1474-4422(24)00426-5. Lancet Neurol. 2024. PMID: 39577922
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