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An essential and highly selective protein import pathway encoded by nucleus-forming phage.
Morgan CJ, Enustun E, Armbruster EG, Birkholz EA, Prichard A, Forman T, Aindow A, Wannasrichan W, Peters S, Inlow K, Shepherd IL, Razavilar A, Chaikeeratisak V, Adler BA, Cress BF, Doudna JA, Pogliano K, Villa E, Corbett KD, Pogliano J. Morgan CJ, et al. Among authors: doudna ja. bioRxiv [Preprint]. 2024 Mar 21:2024.03.21.585822. doi: 10.1101/2024.03.21.585822. bioRxiv. 2024. Update in: Proc Natl Acad Sci U S A. 2024 May 7;121(19):e2321190121. doi: 10.1073/pnas.2321190121 PMID: 38562762 Free PMC article. Updated. Preprint.
Eukaryotic RNA-guided endonucleases evolved from a unique clade of bacterial enzymes.
Yoon PH, Skopintsev P, Shi H, Chen LX, Adler BA, Al-Shimary M, Craig RJ, Li Z, Amerasekera J, Trinidad M, Nisonoff H, Chen K, Lahiri A, Boger R, Jacobsen S, Banfield JF, Doudna JA. Yoon PH, et al. Among authors: doudna ja. bioRxiv [Preprint]. 2023 Aug 10:2023.08.09.552727. doi: 10.1101/2023.08.09.552727. bioRxiv. 2023. Update in: Nucleic Acids Res. 2023 Dec 11;51(22):12414-12427. doi: 10.1093/nar/gkad1053 PMID: 37609353 Free PMC article. Updated. Preprint.
Neuronal DNA repair reveals strategies to influence CRISPR editing outcomes.
Ramadoss GN, Namaganda SJ, Hamilton JR, Sharma R, Chow KG, Macklin BL, Sun M, Liu JC, Fellmann C, Watry HL, Jin J, Perez BS, Sandoval Espinoza CR, Matia MP, Lu SH, Judge LM, Nussenzweig A, Adamson B, Murthy N, Doudna JA, Kampmann M, Conklin BR. Ramadoss GN, et al. Among authors: doudna ja. bioRxiv [Preprint]. 2024 Jun 26:2024.06.25.600517. doi: 10.1101/2024.06.25.600517. bioRxiv. 2024. PMID: 38979269 Free PMC article. Preprint.
Mechanism-guided engineering of a minimal biological particle for genome editing.
Ngo W, Peukes J, Baldwin A, Xue ZW, Hwang S, Stickels RR, Lin Z, Satpathy AT, Wells JA, Schekman R, Nogales E, Doudna JA. Ngo W, et al. Among authors: doudna ja. Proc Natl Acad Sci U S A. 2025 Jan 7;122(1):e2413519121. doi: 10.1073/pnas.2413519121. Epub 2024 Dec 30. Proc Natl Acad Sci U S A. 2025. PMID: 39793042
Functional protein mining with conformal guarantees.
Boger RS, Chithrananda S, Angelopoulos AN, Yoon PH, Jordan MI, Doudna JA. Boger RS, et al. Among authors: doudna ja. Nat Commun. 2025 Jan 2;16(1):85. doi: 10.1038/s41467-024-55676-y. Nat Commun. 2025. PMID: 39747192 Free PMC article.
RNA language models predict mutations that improve RNA function.
Shulgina Y, Trinidad MI, Langeberg CJ, Nisonoff H, Chithrananda S, Skopintsev P, Nissley AJ, Patel J, Boger RS, Shi H, Yoon PH, Doherty EE, Pande T, Iyer AM, Doudna JA, Cate JHD. Shulgina Y, et al. Among authors: doudna ja. Nat Commun. 2024 Dec 5;15(1):10627. doi: 10.1038/s41467-024-54812-y. Nat Commun. 2024. PMID: 39638800 Free PMC article.
SARS-CoV-2 evolution balances conflicting roles of N protein phosphorylation.
Syed AM, Ciling A, Chen IP, Carlson CR, Adly AN, Martin HS, Taha TY, Khalid MM, Price N, Bouhaddou M, Ummadi MR, Moen JM, Krogan NJ, Morgan DO, Ott M, Doudna JA. Syed AM, et al. Among authors: doudna ja. PLoS Pathog. 2024 Nov 21;20(11):e1012741. doi: 10.1371/journal.ppat.1012741. eCollection 2024 Nov. PLoS Pathog. 2024. PMID: 39571001 Free PMC article.
393 results