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Real-World Impact of Olaparib Exposure in Advanced Pancreatic Cancer Patients Harboring Germline BRCA1-2 Pathogenic Variants.
Milella M, Orsi G, di Marco M, Salvatore L, Procaccio L, Noventa S, Bozzarelli S, Garajova I, Vasile E, Giordano G, Macchini M, Cavaliere A, Gaule M, Bergamo F, Chiaravalli M, Palloni A, Carloni R, Bittoni A, Niger M, Rapposelli IG, Rodriquenz MG, Scartozzi M, Mosconi S, Giommoni E, Bernardini I, Paratore C, Spallanzani A, Bencardino K, Forti L, Tamburini E, Lonardi S, Scarpa A, Cascinu S, Tortora G, Sperduti I, Reni M. Milella M, et al. Among authors: lonardi s. Cancer Med. 2025 Feb;14(3):e70364. doi: 10.1002/cam4.70364. Cancer Med. 2025. PMID: 39861955
A constitutive interferon-high immunophenotype defines response to immunotherapy in colorectal cancer.
Acha-Sagredo A, Andrei P, Clayton K, Taggart E, Antoniotti C, Woodman CA, Afrache H, Fourny C, Armero M, Moinudeen HK, Green M, Bhardwaj N, Mikolajczak A, Rodriguez-Lopez M, Crawford M, Connick E, Lim S, Hobson P, Linares J, Ignatova E, Pelka D, Smyth EC, Diamantis N, Sosnowska D, Carullo M, Ciraci P, Bergamo F, Intini R, Nye E, Barral P, Mishto M, Arnold JN, Lonardi S, Cremolini C, Fontana E, Rodriguez-Justo M, Ciccarelli FD. Acha-Sagredo A, et al. Among authors: lonardi s. Cancer Cell. 2025 Jan 13:S1535-6108(24)00483-5. doi: 10.1016/j.ccell.2024.12.008. Online ahead of print. Cancer Cell. 2025. PMID: 39824178 Free article.
Computational pathology applied to clinical colorectal cancer cohorts identifies immune and endothelial cell spatial patterns predictive of outcome.
Trahearn N, Sakr C, Banerjee A, Lee SH, Baker AM, Kocher HM, Angerilli V, Morano F, Bergamo F, Maddalena G, Intini R, Cremolini C, Caravagna G, Graham T, Pietrantonio F, Lonardi S, Fassan M, Sottoriva A. Trahearn N, et al. Among authors: lonardi s. J Pathol. 2025 Feb;265(2):198-210. doi: 10.1002/path.6378. J Pathol. 2025. PMID: 39788558 Free PMC article.
Prognostic impact of depth of response and early tumour shrinkage in patients with BRAF V600E -mutated metastatic colorectal cancer treated with targeted therapy.
Vetere G, Germani MM, Antoniotti C, Salvatore L, Pietrantonio F, Lonardi S, Bensi M, Ghelardi F, Calegari MA, Intini R, Minelli A, Sullo FG, Boccaccio C, Taravella A, Puccini A, Lavacchi D, Noto L, Salati M, Scartozzi M, Cremolini C. Vetere G, et al. Among authors: lonardi s. Ther Adv Med Oncol. 2025 Jan 7;17:17588359241299975. doi: 10.1177/17588359241299975. eCollection 2025. Ther Adv Med Oncol. 2025. PMID: 39776534 Free PMC article.
Early treatment discontinuation in patients with deficient mismatch repair or microsatellite instability high metastatic colorectal cancer receiving immune checkpoint inhibitors.
Taieb J, Ambrosini M, Alouani E, Lonardi S, Sinicrope FA, Decraecker M, Boileve A, Hafliger E, Mazard T, Pernot S, Parent P, Ros J, Overman MJ, Jayachandran P, Nasca V, Salvatore L, Guimbaud R, Cremolini C, Tougeron D, Pietrantonio F. Taieb J, et al. Among authors: lonardi s. J Immunother Cancer. 2025 Jan 4;13(1):e010424. doi: 10.1136/jitc-2024-010424. J Immunother Cancer. 2025. PMID: 39755579 Free PMC article.
MLH1 gene promoter methylation status partially overlaps with CpG methylator phenotype (CIMP) in colorectal adenocarcinoma.
Ceccon C, Borga C, Angerilli V, Bergamo F, Munari G, Sabbadin M, Gasparello J, Schiavi F, Zovato S, Scarpa M, Urso EDL, Dei Tos AP, Luchini C, Grillo F, Lonardi S, Parente P, Fassan M. Ceccon C, et al. Among authors: lonardi s. Pathol Res Pract. 2024 Dec 21;266:155786. doi: 10.1016/j.prp.2024.155786. Online ahead of print. Pathol Res Pract. 2024. PMID: 39724851
Tremelimumab and durvalumab as neoadjuvant or non-operative management strategy of patients with microsatellite instability-high resectable gastric or gastroesophageal junction adenocarcinoma: the INFINITY study by GONO.
Raimondi A, Lonardi S, Murgioni S, Cardellino GG, Tamberi S, Strippoli A, Palermo F, De Manzoni G, Bencivenga M, Bittoni A, Chiodoni C, Lorenzini D, Todoerti K, Manca P, Sangaletti S, Prisciandaro M, Randon G, Nichetti F, Bergamo F, Brich S, Belfiore A, Bertolotti A, Stetco D, Guidi A, Torelli T, Vingiani A, Joshi RP, Khoshdeli M, Beaubier N, Stumpe MC, Nappo F, Leone AG, Pircher CC, Leoncini G, Sabella G, Airo' Farulla L, Alessi A, Morano F, Martinetti A, Niger M, Fassan M, Di Maio M, Kaneva K, Milione M, Nimeiri H, Sposito C, Agnelli L, Mazzaferro V, Di Bartolomeo M, Pietrantonio F. Raimondi A, et al. Among authors: lonardi s. Ann Oncol. 2024 Dec 3:S0923-7534(24)04953-6. doi: 10.1016/j.annonc.2024.11.016. Online ahead of print. Ann Oncol. 2024. PMID: 39637944 Free article.
Early onset metastatic colorectal cancer patients as a distinctive clinical and molecular phenomenon.
Pretta A, Ziranu P, Perissinotto E, Ghelardi F, Marmorino F, Giampieri R, Puci M, De Grandis MC, Lai E, Nasca V, Ciraci P, Puzzoni M, Cerma K, Sciortino C, Taravella A, Pretta G, Giuliani L, Damonte C, Pusceddu V, Sotgiu G, Berardi R, Lonardi S, Bergamo F, Pietrantonio F, Cremolini C, Scartozzi M. Pretta A, et al. Among authors: lonardi s. Br J Cancer. 2025 Feb;132(2):188-194. doi: 10.1038/s41416-024-02902-5. Epub 2024 Nov 27. Br J Cancer. 2025. PMID: 39604610
Nivolumab plus Ipilimumab in Microsatellite-Instability-High Metastatic Colorectal Cancer.
Andre T, Elez E, Van Cutsem E, Jensen LH, Bennouna J, Mendez G, Schenker M, de la Fouchardiere C, Limon ML, Yoshino T, Li J, Lenz HJ, Manzano Mozo JL, Tortora G, Garcia-Carbonero R, Dahan L, Chalabi M, Joshi R, Goekkurt E, Braghiroli MI, Cil T, Cela E, Chen T, Lei M, Dixon M, Abdullaev S, Lonardi S; CheckMate 8HW Investigators. Andre T, et al. Among authors: lonardi s. N Engl J Med. 2024 Nov 28;391(21):2014-2026. doi: 10.1056/NEJMoa2402141. N Engl J Med. 2024. PMID: 39602630 Clinical Trial.
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