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A xanthine-based epithelium-dependent airway relaxant KMUP-3 (7-[2-[4-(4-nitrobenzene)piperazinyl]ethyl]-1,3-dimethylxanthine) increases respiratory performance and protects against tumor necrosis factor-alpha-induced tracheal contraction, involving nitric oxide release and expression of cGMP and protein kinase G.
Lin RJ, Wu BN, Lo YC, An LM, Dai ZK, Lin YT, Tang CS, Chen IJ. Lin RJ, et al. Among authors: dai zk. J Pharmacol Exp Ther. 2006 Feb;316(2):709-17. doi: 10.1124/jpet.105.092171. Epub 2005 Oct 18. J Pharmacol Exp Ther. 2006. PMID: 16234412
156 results