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Pharmacogenomic synthetic lethal screens reveal hidden vulnerabilities and new therapeutic approaches for treatment of NF1-associated tumors.
Williams KB, Larsson AT, Keller BJ, Chaney KE, Williams RL, Bhunia MM, Draper GM, Jubenville TA, Hudson WA, Moertel CL, Ratner N, Largaespada DA. Williams KB, et al. Among authors: moertel cl. bioRxiv [Preprint]. 2024 Nov 1:2024.03.25.585959. doi: 10.1101/2024.03.25.585959. bioRxiv. 2024. PMID: 38585724 Free PMC article. Preprint.
PTEN and NF1 inactivation in Schwann cells produces a severe phenotype in the peripheral nervous system that promotes the development and malignant progression of peripheral nerve sheath tumors.
Keng VW, Rahrmann EP, Watson AL, Tschida BR, Moertel CL, Jessen WJ, Rizvi TA, Collins MH, Ratner N, Largaespada DA. Keng VW, et al. Among authors: moertel cl. Cancer Res. 2012 Jul 1;72(13):3405-13. doi: 10.1158/0008-5472.CAN-11-4092. Epub 2012 Jun 14. Cancer Res. 2012. PMID: 22700876 Free PMC article.
Forward genetic screen for malignant peripheral nerve sheath tumor formation identifies new genes and pathways driving tumorigenesis.
Rahrmann EP, Watson AL, Keng VW, Choi K, Moriarity BS, Beckmann DA, Wolf NK, Sarver A, Collins MH, Moertel CL, Wallace MR, Gel B, Serra E, Ratner N, Largaespada DA. Rahrmann EP, et al. Among authors: moertel cl. Nat Genet. 2013 Jul;45(7):756-66. doi: 10.1038/ng.2641. Epub 2013 May 19. Nat Genet. 2013. PMID: 23685747 Free PMC article.
Co-targeting the MAPK and PI3K/AKT/mTOR pathways in two genetically engineered mouse models of schwann cell tumors reduces tumor grade and multiplicity.
Watson AL, Anderson LK, Greeley AD, Keng VW, Rahrmann EP, Halfond AL, Powell NM, Collins MH, Rizvi T, Moertel CL, Ratner N, Largaespada DA. Watson AL, et al. Among authors: moertel cl. Oncotarget. 2014 Mar 30;5(6):1502-14. doi: 10.18632/oncotarget.1609. Oncotarget. 2014. PMID: 24681606 Free PMC article.
Genetically engineered minipigs model the major clinical features of human neurofibromatosis type 1.
Isakson SH, Rizzardi AE, Coutts AW, Carlson DF, Kirstein MN, Fisher J, Vitte J, Williams KB, Pluhar GE, Dahiya S, Widemann BC, Dombi E, Rizvi T, Ratner N, Messiaen L, Stemmer-Rachamimov AO, Fahrenkrug SC, Gutmann DH, Giovannini M, Moertel CL, Largaespada DA, Watson AL. Isakson SH, et al. Among authors: moertel cl. Commun Biol. 2018 Oct 2;1:158. doi: 10.1038/s42003-018-0163-y. eCollection 2018. Commun Biol. 2018. PMID: 30302402 Free PMC article.
CD200 Checkpoint Reversal: A Novel Approach to Immunotherapy.
Xiong Z, Ampudia Mesias E, Pluhar GE, Rathe SK, Largaespada DA, Sham YY, Moertel CL, Olin MR. Xiong Z, et al. Among authors: moertel cl. Clin Cancer Res. 2020 Jan 1;26(1):232-241. doi: 10.1158/1078-0432.CCR-19-2234. Epub 2019 Oct 17. Clin Cancer Res. 2020. PMID: 31624103
Correction: Co-targeting the MAPK and PI3K/AKT/mTOR pathways in two genetically engineered mouse models of schwann cell tumors reduces tumor grade and multiplicity.
Watson AL, Keller BJ, Williams KA, Damle NN, Finnerty SJ, Anderson LK, Greeley AD, Keng VW, Rahrmann EP, Halfond AL, Powell NM, Collins MH, Rizvi T, Moertel CL, Ratner N, Largaespada DA. Watson AL, et al. Among authors: moertel cl. Oncotarget. 2020 Sep 29;11(39):3618-3620. doi: 10.18632/oncotarget.27349. eCollection 2020 Sep 29. Oncotarget. 2020. PMID: 33062197 Free PMC article.
Selumetinib normalizes Ras/MAPK signaling in clinically relevant neurofibromatosis type 1 minipig tissues in vivo.
Osum SH, Coutts AW, Duerre DJ, Tschida BR, Kirstein MN, Fisher J, Bell WR, Delpuech O, Smith PD, Widemann BC, Moertel CL, Largaespada DA, Watson AL. Osum SH, et al. Among authors: moertel cl. Neurooncol Adv. 2021 Feb 10;3(1):vdab020. doi: 10.1093/noajnl/vdab020. eCollection 2021 Jan-Dec. Neurooncol Adv. 2021. PMID: 33978635 Free PMC article.
62 results