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996 results

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Page 1
CRISPR/Cas9 gene editing in Drosophila via visual selection in a summer classroom.
Kockel L, Zhang V, Wang J, Gulick C, Laws ME, Rajan A, Lantz N, Asgarova A, Dai L, Garcia K, Kim C, Li M, Ordonez-Acosta P, Peng D, Shull H, Tse L, Wang Y, Yu W, Zhou Z, Rankin A, Park S, Kim SK. Kockel L, et al. Among authors: garcia k. bioRxiv [Preprint]. 2024 Mar 30:2024.03.28.587232. doi: 10.1101/2024.03.28.587232. bioRxiv. 2024. PMID: 38585736 Free PMC article. Preprint.
Design of high specificity binders for peptide-MHC-I complexes.
Liu B, Greenwood NF, Bonzanini JE, Motmaen A, Sharp J, Wang C, Visani GM, Vafeados DK, Roullier N, Nourmohammad A, Garcia KC, Baker D. Liu B, et al. Among authors: garcia kc. bioRxiv [Preprint]. 2024 Nov 28:2024.11.28.625793. doi: 10.1101/2024.11.28.625793. bioRxiv. 2024. PMID: 39651227 Free PMC article. Preprint.
Potent antitumor activity of a designed interleukin-21 mimic.
Chun JH, Lim BS, Roy S, Walsh MJ, Abhiraman GC, Zhangxu K, Atajanova T, Revach OY, Clark EC, Li P, Palin CA, Khanna A, Tower S, Kureshi R, Hoffman MT, Sharova T, Lawless A, Cohen S, Boland GM, Nguyen T, Peprah F, Tello JG, Liu SY, Kim CJ, Shin H, Quijano-Rubio A, Jude KM, Gerben S, Murray A, Heine P, DeWitt M, Ulge UY, Carter L, King NP, Silva DA, Kueh HY, Kalia V, Sarkar S, Jenkins RW, Garcia KC, Leonard WJ, Dougan M, Dougan SK, Baker D. Chun JH, et al. Among authors: garcia kc. bioRxiv [Preprint]. 2024 Dec 7:2024.12.06.626481. doi: 10.1101/2024.12.06.626481. bioRxiv. 2024. PMID: 39677740 Free PMC article. Preprint.
FOXP3+ regulatory T cells use heparanase to access IL-2 bound to ECM in inflamed tissues.
Martinez HA, Koliesnik I, Kaber G, Reid JK, Nagy N, Barlow G, Falk BA, Medina CO, Hargil A, Vlodavsky I, Li JP, Pérez-Cruz M, Tang SW, Meyer EH, Wrenshall LE, Lord JD, Garcia KC, Palmer TD, Steinman L, Nepom GT, Wight TN, Bollyky PL, Kuipers HF. Martinez HA, et al. Among authors: garcia kc. bioRxiv [Preprint]. 2023 Feb 27:2023.02.26.529772. doi: 10.1101/2023.02.26.529772. bioRxiv. 2023. Update in: Nat Commun. 2024 Feb 20;15(1):1564. doi: 10.1038/s41467-024-45012-9 PMID: 36909599 Free PMC article. Updated. Preprint.
De novo design of buttressed loops for sculpting protein functions.
Jiang H, Jude KM, Wu K, Fallas J, Ueda G, Brunette TJ, Hicks D, Pyles H, Yang A, Carter L, Lamb M, Li X, Levine PM, Stewart L, Garcia KC, Baker D. Jiang H, et al. Among authors: garcia kc. bioRxiv [Preprint]. 2023 Aug 23:2023.08.22.554384. doi: 10.1101/2023.08.22.554384. bioRxiv. 2023. Update in: Nat Chem Biol. 2024 Aug;20(8):974-980. doi: 10.1038/s41589-024-01632-2 PMID: 37662224 Free PMC article. Updated. Preprint.
AlphaFold2 enables accurate deorphanization of ligands to single-pass receptors.
Danneskiold-Samsøe NB, Kavi D, Jude KM, Nissen SB, Wat LW, Coassolo L, Zhao M, Santana-Oikawa GA, Broido BB, Garcia KC, Svensson KJ. Danneskiold-Samsøe NB, et al. Among authors: garcia kc. bioRxiv [Preprint]. 2023 Dec 15:2023.03.16.531341. doi: 10.1101/2023.03.16.531341. bioRxiv. 2023. Update in: Cell Syst. 2024 Nov 20;15(11):1046-1060.e3. doi: 10.1016/j.cels.2024.10.004 PMID: 36993313 Free PMC article. Updated. Preprint.
De novo design and structure of a peptide-centric TCR mimic binding module.
Householder KD, Xiang X, Jude KM, Deng A, Obenaus M, Wilson SC, Chen X, Wang N, Garcia KC. Householder KD, et al. Among authors: garcia kc. bioRxiv [Preprint]. 2024 Dec 20:2024.12.16.628822. doi: 10.1101/2024.12.16.628822. bioRxiv. 2024. PMID: 39763827 Free PMC article. Preprint.
996 results