Jiang H - Search Results

1

Deep postnatal phenotyping of a new mouse model of nonketotic hyperglycinemia.

Swanson MA, Jiang H, Busquet N, Carlsen J, Brindley C, Benke TA, Van Hove RA, Friederich MW, MacLean KN, Mesches MH, Van Hove JLK. Swanson MA, et al. Among authors: jiang h. bioRxiv [Preprint]. 2024 Mar 29:2024.03.26.586818. doi: 10.1101/2024.03.26.586818. bioRxiv. 2024. Update in: J Inherit Metab Dis. 2024 Sep;47(5):971-990. doi: 10.1002/jimd.12755 PMID: 38586005 Free PMC article. Updated. Preprint.

2

Hyperhomocysteinemia is associated with hypertriglyceridemia in mice with methylenetetrahydrofolate reductase deficiency.

Mikael LG, Wang XL, Wu Q, Jiang H, Maclean KN, Rozen R. Mikael LG, et al. Among authors: jiang h. Mol Genet Metab. 2009 Sep-Oct;98(1-2):187-94. doi: 10.1016/j.ymgme.2009.05.011. Epub 2009 Jun 23. Mol Genet Metab. 2009. PMID: 19560954

3

Constitutive induction of pro-inflammatory and chemotactic cytokines in cystathionine beta-synthase deficient homocystinuria.

Keating AK, Freehauf C, Jiang H, Brodsky GL, Stabler SP, Allen RH, Graham DK, Thomas JA, Van Hove JL, Maclean KN. Keating AK, et al. Among authors: jiang h. Mol Genet Metab. 2011 Aug;103(4):330-7. doi: 10.1016/j.ymgme.2011.04.012. Epub 2011 May 5. Mol Genet Metab. 2011. PMID: 21601502 Free PMC article.

4

Long-term betaine therapy in a murine model of cystathionine beta-synthase deficient homocystinuria: decreased efficacy over time reveals a significant threshold effect between elevated homocysteine and thrombotic risk.

Maclean KN, Jiang H, Greiner LS, Allen RH, Stabler SP. Maclean KN, et al. Among authors: jiang h. Mol Genet Metab. 2012 Mar;105(3):395-403. doi: 10.1016/j.ymgme.2011.11.190. Epub 2011 Dec 2. Mol Genet Metab. 2012. PMID: 22192524

5

Altered expression of apoA-I, apoA-IV and PON-1 activity in CBS deficient homocystinuria in the presence and absence of treatment: possible implications for cardiovascular outcomes.

Jiang H, Stabler SP, Allen RH, Maclean KN. Jiang H, et al. Mol Genet Metab. 2012 Sep;107(1-2):55-65. doi: 10.1016/j.ymgme.2012.04.025. Epub 2012 May 5. Mol Genet Metab. 2012. PMID: 22633282

6

Increased dietary fat contributes to dysregulation of the LKB1/AMPK pathway and increased damage in a mouse model of early-stage ethanol-mediated steatosis.

Shearn CT, Smathers RL, Jiang H, Orlicky DJ, Maclean KN, Petersen DR. Shearn CT, et al. Among authors: jiang h. J Nutr Biochem. 2013 Aug;24(8):1436-45. doi: 10.1016/j.jnutbio.2012.12.002. Epub 2013 Mar 1. J Nutr Biochem. 2013. PMID: 23465594 Free PMC article.

7

Altered hepatic sulfur metabolism in cystathionine β-synthase-deficient homocystinuria: regulatory role of taurine on competing cysteine oxidation pathways.

Jiang H, Stabler SP, Allen RH, Abman SH, Maclean KN. Jiang H, et al. FASEB J. 2014 Sep;28(9):4044-54. doi: 10.1096/fj.14-253633. Epub 2014 Jun 2. FASEB J. 2014. PMID: 24891521 Free PMC article.

8

Sex-specific dysregulation of cysteine oxidation and the methionine and folate cycles in female cystathionine gamma-lyase null mice: a serendipitous model of the methylfolate trap.

Jiang H, Hurt KJ, Breen K, Stabler SP, Allen RH, Orlicky DJ, Maclean KN. Jiang H, et al. Biol Open. 2015 Aug 14;4(9):1154-62. doi: 10.1242/bio.013433. Biol Open. 2015. PMID: 26276101 Free PMC article.

9

Taurine alleviates repression of betaine-homocysteine S-methyltransferase and significantly improves the efficacy of long-term betaine treatment in a mouse model of cystathionine β-synthase-deficient homocystinuria.

Maclean KN, Jiang H, Phinney WN, Keating AK, Hurt KJ, Stabler SP. Maclean KN, et al. Among authors: jiang h. FASEB J. 2019 May;33(5):6339-6353. doi: 10.1096/fj.201802069RR. Epub 2019 Feb 15. FASEB J. 2019. PMID: 30768359

Collectively, our findings indicate that adjuvantial taurine treatment has the potential to significantly improve clinical outcomes in HCU.-Maclean, K. N., Jiang, H, Phinney, W. N., Keating, A. K., Hurt, K. J., Stabler, S. P. Taurine alleviates repression of betaine …

Collectively, our findings indicate that adjuvantial taurine treatment has the potential to significantly improve clinical outcomes in HCU.- …

10

Biomarkers of oxidative stress, inflammation, and vascular dysfunction in inherited cystathionine β-synthase deficient homocystinuria and the impact of taurine treatment in a phase 1/2 human clinical trial.

Van Hove JLK, Freehauf CL, Ficicioglu C, Pena LDM, Moreau KL, Henthorn TK, Christians U, Jiang H, Cowan TM, Young SP, Hite M, Friederich MW, Stabler SP, Spector EB, Kronquist KE, Thomas JA, Emmett P, Harrington MJ, Pyle L, Creadon-Swindell G, Wempe MF, MacLean KN. Van Hove JLK, et al. Among authors: jiang h. J Inherit Metab Dis. 2019 May;42(3):424-437. doi: 10.1002/jimd.12085. Epub 2019 Apr 11. J Inherit Metab Dis. 2019. PMID: 30873612 Clinical Trial.

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