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Page 1
Haploinsufficiency of phosphodiesterase 10A activates PI3K/AKT signaling independent of PTEN to induce an aggressive glioma phenotype.
Nuechterlein N, Shelbourn A, Szulzewsky F, Arora S, Casad M, Pattwell S, Merino-Galan L, Sulman E, Arowa S, Alvinez N, Jung M, Brown D, Tang K, Jackson S, Stoica S, Chittaboina P, Banasavadi-Siddegowda YK, Wirsching HG, Stella N, Shapiro L, Paddison P, Patel AP, Gilbert MR, Abdullaev Z, Aldape K, Pratt D, Holland EC, Cimino PJ. Nuechterlein N, et al. Among authors: banasavadi siddegowda yk. Genes Dev. 2024 Apr 17;38(5-6):273-288. doi: 10.1101/gad.351350.123. Genes Dev. 2024. PMID: 38589034 Free PMC article.
PKR induces TGF-β and limits oncolytic immune therapy.
Hong B, Sahu U, Mullarkey MP, Hong E, Pei G, Yan Y, Otani Y, Banasavadi-Siddegowda Y, Fan H, Zhao Z, Yu J, Caligiuri MA, Kaur B. Hong B, et al. J Immunother Cancer. 2023 Feb;11(2):e006164. doi: 10.1136/jitc-2022-006164. J Immunother Cancer. 2023. PMID: 36796878 Free PMC article.
Differential expression of an endogenous retroviral element [HERV-K(HML-6)] is associated with reduced survival in glioblastoma patients.
Shah AH, Govindarajan V, Doucet-O'Hare TT, Rivas S, Ampie L, DeMarino C, Banasavadi-Siddegowda YK, Zhang Y, Johnson KR, Almsned F, Gilbert MR, Heiss JD, Nath A. Shah AH, et al. Among authors: banasavadi siddegowda yk. Sci Rep. 2022 Apr 27;12(1):6902. doi: 10.1038/s41598-022-10914-5. Sci Rep. 2022. PMID: 35477752 Free PMC article.
Human endogenous retrovirus K contributes to a stem cell niche in glioblastoma.
Shah AH, Rivas SR, Doucet-O'Hare TT, Govindarajan V, DeMarino C, Wang T, Ampie L, Zhang Y, Banasavadi-Siddegowda YK, Walbridge S, Maric D, Garcia-Montojo M, Suter RK, Lee MH, Zaghloul KA, Steiner J, Elkahloun AG, Chandar J, Seetharam D, Desgraves J, Li W, Johnson K, Ivan ME, Komotar RJ, Gilbert MR, Heiss JD, Nath A. Shah AH, et al. Among authors: banasavadi siddegowda yk. J Clin Invest. 2023 Jul 3;133(13):e167929. doi: 10.1172/JCI167929. J Clin Invest. 2023. PMID: 37395282 Free PMC article.
Inhibiting protein phosphatase 2A increases the antitumor effect of protein arginine methyltransferase 5 inhibition in models of glioblastoma.
Otani Y, Sur HP, Rachaiah G, Namagiri S, Chowdhury A, Lewis CT, Shimizu T, Gangaplara A, Wang X, Vézina A, Maric D, Jackson S, Yan Y, Zhengping Z, Ray-Chaudhury A, Kumar S, Ballester LY, Chittiboina P, Yoo JY, Heiss J, Kaur B, Banasavadi-Siddegowda YK. Otani Y, et al. Neuro Oncol. 2021 Sep 1;23(9):1481-1493. doi: 10.1093/neuonc/noab014. Neuro Oncol. 2021. PMID: 33556161 Free PMC article.
FKBP38 Regulates Self-Renewal and Survival of GBM Neurospheres.
Dowling AL, Walbridge S, Ertekin C, Namagiri S, Camacho K, Chowdhury A, Bryant JP, Kohut E, Heiss JD, Brown DA, Kumbar SG, Banasavadi-Siddegowda YK. Dowling AL, et al. Among authors: banasavadi siddegowda yk. Cells. 2023 Nov 2;12(21):2562. doi: 10.3390/cells12212562. Cells. 2023. PMID: 37947640 Free PMC article.
NOTCH-Induced MDSC Recruitment after oHSV Virotherapy in CNS Cancer Models Modulates Antitumor Immunotherapy.
Otani Y, Yoo JY, Lewis CT, Chao S, Swanner J, Shimizu T, Kang JM, Murphy SA, Rivera-Caraballo K, Hong B, Glorioso JC, Nakashima H, Lawler SE, Banasavadi-Siddegowda Y, Heiss JD, Yan Y, Pei G, Caligiuri MA, Zhao Z, Chiocca EA, Yu J, Kaur B. Otani Y, et al. Clin Cancer Res. 2022 Apr 1;28(7):1460-1473. doi: 10.1158/1078-0432.CCR-21-2347. Clin Cancer Res. 2022. PMID: 35022322 Free PMC article.
Targeting protein arginine methyltransferase 5 sensitizes glioblastoma to trametinib.
Banasavadi-Siddegowda YK, Namagiri S, Otani Y, Sur H, Rivas S, Bryant JP, Shellbourn A, Rock M, Chowdhury A, Lewis CT, Shimizu T, Walbridge S, Kumarasamy S, Shah AH, Lee TJ, Maric D, Yan Y, Yoo JY, Kumbar SG, Heiss JD, Kaur B. Banasavadi-Siddegowda YK, et al. Neurooncol Adv. 2022 Jun 20;4(1):vdac095. doi: 10.1093/noajnl/vdac095. eCollection 2022 Jan-Dec. Neurooncol Adv. 2022. PMID: 35875691 Free PMC article.
PTEN expression by an oncolytic herpesvirus directs T-cell mediated tumor clearance.
Russell L, Swanner J, Jaime-Ramirez AC, Wang Y, Sprague A, Banasavadi-Siddegowda Y, Yoo JY, Sizemore GM, Kladney R, Zhang J, Lehman NL, Ostrowski MC, Hong B, Caligiuri M, Yu J, Kaur B. Russell L, et al. Nat Commun. 2018 Nov 27;9(1):5006. doi: 10.1038/s41467-018-07344-1. Nat Commun. 2018. PMID: 30479334 Free PMC article.
31 results