Dömling ASS - Search Results

1

Small-Molecule Allosteric Inhibitors of Human Aspartate Transcarbamoylase Suppress Proliferation of Bone Osteosarcoma Epithelial Cells.

Wang C, Zhang B, Cong Y, Du X, Chen S, Visser L, Ruiz-Moreno AJ, Zhang L, Reggiori F, Dömling ASS, Groves MR. Wang C, et al. Among authors: domling ass. ChemMedChem. 2024 Jul 2;19(13):e202300688. doi: 10.1002/cmdc.202300688. Epub 2024 May 22. ChemMedChem. 2024. PMID: 38602859

2

Inhibitors of Aspartate Transcarbamoylase Inhibit Mycobacterium tuberculosis Growth.

Du X, Sonawane V, Zhang B, Wang C, de Ruijter B, Dömling ASS, Reiling N, Groves MR. Du X, et al. Among authors: domling ass. ChemMedChem. 2023 Sep 1;18(17):e202300279. doi: 10.1002/cmdc.202300279. Epub 2023 Jun 30. ChemMedChem. 2023. PMID: 37294060

3

Discovery of Small-Molecule Allosteric Inhibitors of PfATC as Antimalarials.

Wang C, Zhang B, Krüger A, Du X, Visser L, Dömling ASS, Wrenger C, Groves MR. Wang C, et al. Among authors: domling ass. J Am Chem Soc. 2022 Oct 19;144(41):19070-19077. doi: 10.1021/jacs.2c08128. Epub 2022 Oct 4. J Am Chem Soc. 2022. PMID: 36195578 Free PMC article.

4

Pharmacological Rationale for Targeting IL-17 in Asthma.

Rahmawati SF, Te Velde M, Kerstjens HAM, Dömling ASS, Groves MR, Gosens R. Rahmawati SF, et al. Among authors: domling ass. Front Allergy. 2021 Aug 30;2:694514. doi: 10.3389/falgy.2021.694514. eCollection 2021. Front Allergy. 2021. PMID: 35387016 Free PMC article. Review.

5

A fragment-based approach identifies an allosteric pocket that impacts malate dehydrogenase activity.

Reyes Romero A, Lunev S, Popowicz GM, Calderone V, Gentili M, Sattler M, Plewka J, Taube M, Kozak M, Holak TA, Dömling ASS, Groves MR. Reyes Romero A, et al. Among authors: domling ass. Commun Biol. 2021 Aug 10;4(1):949. doi: 10.1038/s42003-021-02442-1. Commun Biol. 2021. PMID: 34376783 Free PMC article.

6

Molecular Target Validation of Aspartate Transcarbamoylase from Plasmodium falciparum by Torin 2.

Bosch SS, Lunev S, Batista FA, Linzke M, Kronenberger T, Dömling ASS, Groves MR, Wrenger C. Bosch SS, et al. Among authors: domling ass. ACS Infect Dis. 2020 May 8;6(5):986-999. doi: 10.1021/acsinfecdis.9b00411. Epub 2020 Mar 12. ACS Infect Dis. 2020. PMID: 32129597

7

Oligomeric protein interference validates druggability of aspartate interconversion in Plasmodium falciparum.

Batista FA, Bosch SS, Butzloff S, Lunev S, Meissner KA, Linzke M, Romero AR, Wang C, Müller IB, Dömling ASS, Groves MR, Wrenger C. Batista FA, et al. Among authors: domling ass. Microbiologyopen. 2019 Jul;8(7):e00779. doi: 10.1002/mbo3.779. Epub 2019 Feb 28. Microbiologyopen. 2019. PMID: 30821109 Free PMC article.

8

Identification of potential antivirulence agents by substitution-oriented screening for inhibitors of Streptococcus pyogenes sortase A.

Wójcik M, Eleftheriadis N, Zwinderman MRH, Dömling ASS, Dekker FJ, Boersma YL. Wójcik M, et al. Among authors: domling ass. Eur J Med Chem. 2019 Jan 1;161:93-100. doi: 10.1016/j.ejmech.2018.10.027. Epub 2018 Oct 15. Eur J Med Chem. 2019. PMID: 30343193

9

Identification of a non-competitive inhibitor of Plasmodium falciparum aspartate transcarbamoylase.

Lunev S, Bosch SS, Batista FA, Wang C, Li J, Linzke M, Kruithof P, Chamoun G, Dömling ASS, Wrenger C, Groves MR. Lunev S, et al. Among authors: domling ass. Biochem Biophys Res Commun. 2018 Mar 11;497(3):835-842. doi: 10.1016/j.bbrc.2018.02.112. Epub 2018 Feb 21. Biochem Biophys Res Commun. 2018. PMID: 29476738 Free article.

10

A Systematic Protein Refolding Screen Method using the DGR Approach Reveals that Time and Secondary TSA are Essential Variables.

Wang Y, van Oosterwijk N, Ali AM, Adawy A, Anindya AL, Dömling ASS, Groves MR. Wang Y, et al. Among authors: domling ass. Sci Rep. 2017 Aug 24;7(1):9355. doi: 10.1038/s41598-017-09687-z. Sci Rep. 2017. PMID: 28839267 Free PMC article.

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