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Page 1
Synergism between remdesivir and ribavirin leads to SARS-CoV-2 extinction in cell culture.
García-Crespo C, de Ávila AI, Gallego I, Soria ME, Durán-Pastor A, Somovilla P, Martínez-González B, Muñoz-Flores J, Mínguez P, Salar-Vidal L, Esteban-Muñoz M, Cañar-Camacho E, Ferrer-Orta C, Zuñiga S, Sola I, Enjuanes L, Esteban J, Fernández-Roblas R, Gadea I, Gómez J, Verdaguer N, Domingo E, Perales C. García-Crespo C, et al. Among authors: enjuanes l. Br J Pharmacol. 2024 Aug;181(15):2636-2654. doi: 10.1111/bph.16344. Epub 2024 Apr 14. Br J Pharmacol. 2024. PMID: 38616133
SARS-CoV-2 Mac1 is required for IFN antagonism and efficient virus replication in mice.
Alhammad YM, Parthasarathy S, Ghimire R, O'Connor JJ, Kerr CM, Pfannenstiel JJ, Chanda D, Miller CA, Unckless RL, Zuniga S, Enjuanes L, More S, Channappanavar R, Fehr AR. Alhammad YM, et al. Among authors: enjuanes l. bioRxiv [Preprint]. 2023 Apr 6:2023.04.06.535927. doi: 10.1101/2023.04.06.535927. bioRxiv. 2023. Update in: Proc Natl Acad Sci U S A. 2023 Aug 29;120(35):e2302083120. doi: 10.1073/pnas.2302083120 PMID: 37066301 Free PMC article. Updated. Preprint.
Plitidepsin has a positive therapeutic index in adult patients with COVID-19 requiring hospitalization.
Varona JF, Landete P, Lopez-Martin JA, Estrada V, Paredes R, Guisado-Vasco P, de Orueta LF, Torralba M, Fortún J, Vates R, Barberán J, Clotet B, Ancochea J, Carnevali D, Cabello N, Porras L, Gijón P, Monereo A, Abad D, Zúñiga S, Sola I, Rodon J, Izquierdo-Useros N, Fudio S, Pontes MJ, de Rivas B, Girón de Velasco P, Sopesén B, Nieto A, Gómez J, Avilés P, Lubomirov R, White KM, Rosales R, Yildiz S, Reuschl AK, Thorne LG, Jolly C, Towers GJ, Zuliani-Alvarez L, Bouhaddou M, Obernier K, Enjuanes L, Fernández-Sousa JM; Plitidepsin – COVID - 19 Study Group; Krogan NJ, Jimeno JM, García-Sastre A. Varona JF, et al. Among authors: enjuanes l. medRxiv [Preprint]. 2021 May 25:2021.05.25.21257505. doi: 10.1101/2021.05.25.21257505. medRxiv. 2021. Update in: Life Sci Alliance. 2022 Jan 10;5(4):e202101200. doi: 10.26508/lsa.202101200 PMID: 34075384 Free PMC article. Updated. Preprint.
Biocompatible Iron Oxide Nanoparticles Display Antiviral Activity Against Two Different Respiratory Viruses in Mice.
DeDiego ML, Portilla Y, Daviu N, López-García D, Villamayor L, Vázquez-Utrilla P, Mulens-Arias V, Pérez-Yagüe S, Nogales A, Ovejero JG, Gallo-Cordova A, Enjuanes L, Veintemillas-Verdaguer S, Morales MP, Barber DF. DeDiego ML, et al. Among authors: enjuanes l. Int J Nanomedicine. 2024 Dec 21;19:13763-13788. doi: 10.2147/IJN.S475323. eCollection 2024. Int J Nanomedicine. 2024. PMID: 39723174 Free PMC article.
Interaction between SARS-CoV PBM and Cellular PDZ Domains Leading to Virus Virulence.
Honrubia JM, Valverde JR, Muñoz-Santos D, Ripoll-Gómez J, de la Blanca N, Izquierdo J, Villarejo-Torres M, Marchena-Pasero A, Rueda-Huélamo M, Nombela I, Ruiz-Yuste M, Zuñiga S, Sola I, Enjuanes L. Honrubia JM, et al. Among authors: enjuanes l. Viruses. 2024 Jul 29;16(8):1214. doi: 10.3390/v16081214. Viruses. 2024. PMID: 39205188 Free PMC article.
Correction for Castaño-Rodriguez et al., "Role of Severe Acute Respiratory Syndrome Coronavirus Viroporins E, 3a, and 8a in Replication and Pathogenesis".
Castaño-Rodríguez C, Honrubia JM, Gutierrez-Álvarez J, DeDiego ML, Nieto-Torres JL, Jimenez-Guardeño JM, Regla-Nava JA, Fernandez-Delgado R, Verdia-Báguena C, Queralt-Martín M, Kochan G, Perlman S, Aguilella VM, Sola I, Enjuanes L. Castaño-Rodríguez C, et al. Among authors: enjuanes l. mBio. 2023 Dec 19;14(6):e0248523. doi: 10.1128/mbio.02485-23. Epub 2023 Nov 10. mBio. 2023. PMID: 37947413 Free PMC article. No abstract available.
Cell type dependent stability and virulence of a recombinant SARS-CoV-2, and engineering of a propagation deficient RNA replicon to analyze virus RNA synthesis.
Wang L, Guzman M, Muñoz-Santos D, Honrubia JM, Ripoll-Gomez J, Delgado R, Sola I, Enjuanes L, Zuñiga S. Wang L, et al. Among authors: enjuanes l. Front Cell Infect Microbiol. 2023 Oct 24;13:1268227. doi: 10.3389/fcimb.2023.1268227. eCollection 2023. Front Cell Infect Microbiol. 2023. PMID: 37942479 Free PMC article.
SARS-CoV-2 ORF8 accessory protein is a virulence factor.
Bello-Perez M, Hurtado-Tamayo J, Mykytyn AZ, Lamers MM, Requena-Platek R, Schipper D, Muñoz-Santos D, Ripoll-Gómez J, Esteban A, Sánchez-Cordón PJ, Enjuanes L, Haagmans BL, Sola I. Bello-Perez M, et al. Among authors: enjuanes l. mBio. 2023 Oct 31;14(5):e0045123. doi: 10.1128/mbio.00451-23. Epub 2023 Aug 25. mBio. 2023. PMID: 37623322 Free PMC article.
SARS-CoV-2 Mac1 is required for IFN antagonism and efficient virus replication in cell culture and in mice.
Alhammad YM, Parthasarathy S, Ghimire R, Kerr CM, O'Connor JJ, Pfannenstiel JJ, Chanda D, Miller CA, Baumlin N, Salathe M, Unckless RL, Zuñiga S, Enjuanes L, More S, Channappanavar R, Fehr AR. Alhammad YM, et al. Among authors: enjuanes l. Proc Natl Acad Sci U S A. 2023 Aug 29;120(35):e2302083120. doi: 10.1073/pnas.2302083120. Epub 2023 Aug 22. Proc Natl Acad Sci U S A. 2023. PMID: 37607224 Free PMC article.
Dextran sulfate from Leuconostoc mesenteroides B512F exerts potent antiviral activity against SARS-CoV-2 in vitro and in vivo.
Andreu S, von Kobbe C, Delgado P, Ripa I, Buzón MJ, Genescà M, Gironès N, Del Moral-Salmoral J, Ramírez GA, Zúñiga S, Enjuanes L, López-Guerrero JA, Bello-Morales R. Andreu S, et al. Among authors: enjuanes l. Front Microbiol. 2023 May 3;14:1185504. doi: 10.3389/fmicb.2023.1185504. eCollection 2023. Front Microbiol. 2023. PMID: 37206325 Free PMC article.
254 results