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359 results

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Page 1
Proximally biased V(D)J recombination in the clonal evolution of IGH alleles in KMT2A::AFF1 BCP-ALL of all age classes.
Müller H, Dicker F, Bär C, Walter W, Hutter S, Nadarajah N, Meggendorfer M, Gao Q, Iacobucci I, Mullighan CG, Kern W, Haferlach T, Haferlach C. Müller H, et al. Among authors: mullighan cg. Hemasphere. 2024 Apr 22;8(4):e71. doi: 10.1002/hem3.71. eCollection 2024 Apr. Hemasphere. 2024. PMID: 38650597 Free PMC article. No abstract available.
Stromal-induced epithelial-mesenchymal transition induces targetable drug resistance in acute lymphoblastic leukemia.
Park CS, Yoshihara H, Gao Q, Qu C, Iacobucci I, Ghate PS, Connelly JP, Pruett-Miller SM, Wagner B, Robinson CG, Mishra A, Peng J, Yang L, Rankovic Z, Finkelstein D, Luger S, Litzow M, Paietta EM, Hebbar N, Velasquez MP, Mullighan CG. Park CS, et al. Among authors: mullighan cg. Cell Rep. 2023 Jul 25;42(7):112804. doi: 10.1016/j.celrep.2023.112804. Epub 2023 Jul 14. Cell Rep. 2023. PMID: 37453060 Free PMC article.
CASZ1 upregulates PI3K-AKT-mTOR signaling and promotes T-cell acute lymphoblastic leukemia.
Cardoso BA, Duque M, Gírio A, Fragoso R, Oliveira ML, Allen JR, Martins LR, Correia NC, Silveira AB, Veloso A, Kimura S, Demoen L, Matthijssens F, Jeha S, Cheng C, Pui CH, Grosso AR, Neto JL, De Almeida SF, Van Vlieberghe P, Mullighan CG, Yunes JA, Langenau DM, Pflumio F, Barata JT. Cardoso BA, et al. Among authors: mullighan cg. Haematologica. 2024 Jun 1;109(6):1713-1725. doi: 10.3324/haematol.2023.282854. Haematologica. 2024. PMID: 38058200 Free PMC article.
Elevated enhancer-oncogene contacts and higher oncogene expression levels by recurrent CTCF inactivating mutations in acute T cell leukemia.
Smits WK, Vermeulen C, Hagelaar R, Kimura S, Vroegindeweij EM, Buijs-Gladdines JGCAM, van de Geer E, Verstegen MJAM, Splinter E, van Reijmersdal SV, Buijs A, Galjart N, van Eyndhoven W, van Min M, Kuiper R, Kemmeren P, Mullighan CG, de Laat W, Meijerink JPP. Smits WK, et al. Among authors: mullighan cg. Cell Rep. 2023 Apr 25;42(4):112373. doi: 10.1016/j.celrep.2023.112373. Epub 2023 Apr 14. Cell Rep. 2023. PMID: 37060567 Free PMC article.
An inflammatory state defines a high-risk T-lineage acute lymphoblastic leukemia subgroup.
Gower M, Li X, Aguilar-Navarro AG, Lin B, Fernandez M, Edun G, Nader M, Rondeau V, Arruda A, Tierens A, Eames Seffernick A, Pölönen P, Durocher J, Wagenblast E, Yang L, Lee HS, Mullighan CG, Teachey D, Rashkovan M, Tremblay CS, Herranz D, Itkin T, Loghavi S, Dick JE, Schwartz G, Perusini MA, Sibai H, Hitzler J, Gruber TA, Minden M, Jones CL, Dolgalev I, Jahangiri S, Tikhonova AN. Gower M, et al. Among authors: mullighan cg. Sci Transl Med. 2025 Jan;17(779):eadr2012. doi: 10.1126/scitranslmed.adr2012. Epub 2025 Jan 1. Sci Transl Med. 2025. PMID: 39742502
Reply to: Accurate Determinants of Outcome in ALL.
Chang TC, Chen W, Qu C, Cheng Z, Elsayed A, Pounds SB, Shago M, Rabin KR, Raetz EA, Devidas M, Cheng C, Angiolillo A, Baviskar P, Borowitz M, Burke MJ, Carroll A, Carroll WL, Chen IM, Harvey R, Heerema N, Iacobucci I, Wang JR, Jeha S, Larsen E, Mattano L, Maloney K, Pui CH, Ramirez NC, Salzer W, Willman C, Winick N, Wood B, Hunger SP, Wu G, Mullighan CG, Loh ML. Chang TC, et al. Among authors: mullighan cg. J Clin Oncol. 2024 Dec 23:JCO2402335. doi: 10.1200/JCO-24-02335. Online ahead of print. J Clin Oncol. 2024. PMID: 39715469 No abstract available.
Clinical significance of Philadelphia-like-related genes in a resource-constrained setting of adult B-acute lymphoblastic leukemia patients.
Lima K, Rojas CAO, Nogueira FL, da Silva WF, Cavaglieri RC, Nardinelli L, Leal AM, Velloso EDRP, Bendit I, Alencar A, Mullighan CG, Machado-Neto JA, Rego EM. Lima K, et al. Among authors: mullighan cg. EJHaem. 2024 Oct 7;5(6):1366-1369. doi: 10.1002/jha2.1030. eCollection 2024 Dec. EJHaem. 2024. PMID: 39691248 Free PMC article. No abstract available.
A multiomic atlas identifies a treatment-resistant, bone marrow progenitor-like cell population in T cell acute lymphoblastic leukemia.
Xu J, Chen C, Sussman JH, Yoshimura S, Vincent T, Pölönen P, Hu J, Bandyopadhyay S, Elghawy O, Yu W, Tumulty J, Chen CH, Li EY, Diorio C, Shraim R, Newman H, Uppuluri L, Li A, Chen GM, Wu DW, Ding YY, Xu JA, Karanfilovski D, Lim T, Hsu M, Thadi A, Ahn KJ, Wu CY, Peng J, Sun Y, Wang A, Mehta R, Frank D, Meyer L, Loh ML, Raetz EA, Chen Z, Wood BL, Devidas M, Dunsmore KP, Winter SS, Chang TC, Wu G, Pounds SB, Zhang NR, Carroll W, Hunger SP, Bernt K, Yang JJ, Mullighan CG, Tan K, Teachey DT. Xu J, et al. Among authors: mullighan cg. Nat Cancer. 2024 Nov 25. doi: 10.1038/s43018-024-00863-5. Online ahead of print. Nat Cancer. 2024. PMID: 39587259
Genomic profiling of circulating tumor DNA for childhood cancers.
Lei S, Jia S, Takalkar S, Chang TC, Ma X, Szlachta K, Xu K, Cheng Z, Hui Y, Koo SC, Mead PE, Gao Q, Kumar P, Bailey CP, Sunny J, Pappo AS, Federico SM, Robinson GW, Gajjar A, Rubnitz JE, Jeha S, Pui CH, Inaba H, Wu G, Klco JM, Tatevossian RG, Mullighan CG. Lei S, et al. Among authors: mullighan cg. Leukemia. 2024 Nov 10. doi: 10.1038/s41375-024-02461-x. Online ahead of print. Leukemia. 2024. PMID: 39523434
MLL oncoprotein levels influence leukemia lineage identities.
Janssens DH, Duran M, Otto DJ, Wu W, Xu Y, Kirkey D, Mullighan CG, Yi JS, Meshinchi S, Sarthy JF, Ahmad K, Henikoff S. Janssens DH, et al. Among authors: mullighan cg. Nat Commun. 2024 Oct 29;15(1):9341. doi: 10.1038/s41467-024-53399-8. Nat Commun. 2024. PMID: 39472576 Free PMC article.
359 results