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In vitro to in vivo extrapolation to derive a metabolism factor for estimating the aggregate exposure to salicylic acid after dermal exposure of its esters.
Najjar A, Grégoire S, Nicol B, Natsch A, Golbamaki N, Boisleve F, Irizar A, Wall B, Swinscoe A, Masini-Etévé V, Selechnik D, Api AM, Griem P, Hewitt N, Cardamone E. Najjar A, et al. Among authors: hewitt n. Arch Toxicol. 2024 Jul;98(7):2199-2211. doi: 10.1007/s00204-024-03749-8. Epub 2024 Apr 24. Arch Toxicol. 2024. PMID: 38658404 Free PMC article.
Development of a microphysiological skin-liver-thyroid Chip3 model and its application to evaluate the effects on thyroid hormones of topically applied cosmetic ingredients under consumer-relevant conditions.
Tao TP, Maschmeyer I, LeCluyse EL, Rogers E, Brandmair K, Gerlach S, Przibilla J, Kern F, Genies C, Jacques C, Najjar A, Schepky A, Marx U, Kühnl J, Hewitt NJ. Tao TP, et al. Front Pharmacol. 2023 Feb 8;14:1076254. doi: 10.3389/fphar.2023.1076254. eCollection 2023. Front Pharmacol. 2023. PMID: 36843954 Free PMC article.
In vitro pharmacologic profiling aids systemic toxicity assessment of chemicals.
Burbank M, Kukic P, Ouedraogo G, Kenna JG, Hewitt NJ, Armstrong D, Otto-Bruc A, Ebmeyer J, Boettcher M, Willox I, Mahony C. Burbank M, et al. Among authors: hewitt nj. Toxicol Appl Pharmacol. 2024 Nov;492:117131. doi: 10.1016/j.taap.2024.117131. Epub 2024 Oct 20. Toxicol Appl Pharmacol. 2024. PMID: 39437896 Free article.
176 results