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Inhibition of asparagine synthetase effectively retards polycystic kidney disease progression.
Clerici S, Podrini C, Stefanoni D, Distefano G, Cassina L, Steidl ME, Tronci L, Canu T, Chiaravalli M, Spies D, Bell TA 3rd, Costa AS, Esposito A, D'Alessandro A, Frezza C, Bachi A, Boletta A. Clerici S, et al. Among authors: distefano g. EMBO Mol Med. 2024 Jun;16(6):1379-1403. doi: 10.1038/s44321-024-00071-9. Epub 2024 Apr 29. EMBO Mol Med. 2024. PMID: 38684863 Free PMC article.
Primary cilia sense glutamine availability and respond via asparagine synthetase.
Steidl ME, Nigro EA, Nielsen AK, Pagliarini R, Cassina L, Lampis M, Podrini C, Chiaravalli M, Mannella V, Distefano G, Yang M, Aslanyan M, Musco G, Roepman R, Frezza C, Boletta A. Steidl ME, et al. Among authors: distefano g. Nat Metab. 2023 Mar;5(3):385-397. doi: 10.1038/s42255-023-00754-6. Epub 2023 Mar 6. Nat Metab. 2023. PMID: 36879119 Free PMC article.
Oncogene-induced maladaptive activation of trained immunity in the pathogenesis and treatment of Erdheim-Chester disease.
Molteni R, Biavasco R, Stefanoni D, Nemkov T, Domínguez-Andrés J, Arts RJ, Merelli I, Mazza D, Zambrano S, Panigada M, Cantoni E, Tengesdal IW, Maksud P, Piras F, Cesana D, Cassina L, Distefano G, Loffreda A, Gnani D, De Luca G, Tomelleri A, Campochiaro C, Joosten LAB, Dinarello CA, Kajaste-Rudnitski A, Haroche J, Cardaci S, Cenci S, Dagna L, Doglioni C, Ferrarini M, Ferrero E, Boletta A, D'Alessandro A, Montini E, Netea MG, Cavalli G. Molteni R, et al. Among authors: distefano g. Blood. 2021 Oct 28;138(17):1554-1569. doi: 10.1182/blood.2020009594. Blood. 2021. PMID: 34077954 Free article.
248 results