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Page 1
Multitarget μ-Opioid Receptor Agonists─Neuropeptide FF Receptor Antagonists Induce Potent Antinociception with Reduced Adverse Side Effects.
De Neve J, Elhabazi K, Gonzalez S, Herby C, Schneider S, Utard V, Fellmann-Clauss R, Petit-Demouliere N, Lecat S, Kremer M, Ces A, Daubeuf F, Martin C, Ballet S, Bihel F, Simonin F. De Neve J, et al. Among authors: utard v. J Med Chem. 2024 May 9;67(9):7603-7619. doi: 10.1021/acs.jmedchem.4c00442. Epub 2024 Apr 30. J Med Chem. 2024. PMID: 38687204
Identification of an N-acylated-DArg-Leu-NH2 Dipeptide as a Highly Selective Neuropeptide FF1 Receptor Antagonist That Potently Prevents Opioid-Induced Hyperalgesia.
Quillet R, Schneider S, Utard V, Drieu la Rochelle A, Elhabazi K, Henningsen JB, Gizzi P, Schmitt M, Kugler V, Simonneaux V, Ilien B, Simonin F, Bihel F. Quillet R, et al. Among authors: utard v. J Med Chem. 2021 Jun 10;64(11):7555-7564. doi: 10.1021/acs.jmedchem.1c00256. Epub 2021 May 19. J Med Chem. 2021. PMID: 34008968
A bifunctional-biased mu-opioid agonist-neuropeptide FF receptor antagonist as analgesic with improved acute and chronic side effects.
Drieu la Rochelle A, Guillemyn K, Dumitrascuta M, Martin C, Utard V, Quillet R, Schneider S, Daubeuf F, Willemse T, Mampuys P, Maes BUW, Frossard N, Bihel F, Spetea M, Simonin F, Ballet S. Drieu la Rochelle A, et al. Among authors: utard v. Pain. 2018 Sep;159(9):1705-1718. doi: 10.1097/j.pain.0000000000001262. Pain. 2018. PMID: 29708942
RF313, an orally bioavailable neuropeptide FF receptor antagonist, opposes effects of RF-amide-related peptide-3 and opioid-induced hyperalgesia in rodents.
Elhabazi K, Humbert JP, Bertin I, Quillet R, Utard V, Schneider S, Schmitt M, Bourguignon JJ, Laboureyras E, Ben Boujema M, Simonnet G, Ancel C, Simonneaux V, Beltramo M, Bucher B, Sorg T, Meziane H, Schneider E, Petit-Demoulière B, Ilien B, Bihel F, Simonin F. Elhabazi K, et al. Among authors: utard v. Neuropharmacology. 2017 May 15;118:188-198. doi: 10.1016/j.neuropharm.2017.03.012. Epub 2017 Mar 10. Neuropharmacology. 2017. PMID: 28288815
Bifunctional Peptide-Based Opioid Agonist-Nociceptin Antagonist Ligands for Dual Treatment of Acute and Neuropathic Pain.
Guillemyn K, Starnowska J, Lagard C, Dyniewicz J, Rojewska E, Mika J, Chung NN, Utard V, Kosson P, Lipkowski AW, Chevillard L, Arranz-Gibert P, Teixidó M, Megarbane B, Tourwé D, Simonin F, Przewlocka B, Schiller PW, Ballet S. Guillemyn K, et al. Among authors: utard v. J Med Chem. 2016 Apr 28;59(8):3777-92. doi: 10.1021/acs.jmedchem.5b01976. Epub 2016 Apr 14. J Med Chem. 2016. PMID: 27035422 Free PMC article.
Neuropeptide FF receptors as novel targets for limbic seizure attenuation.
Portelli J, Meurs A, Bihel F, Hammoud H, Schmitt M, De Kock J, Utard V, Humbert JP, Bertin I, Buffel I, Coppens J, Tourwe D, Maes V, De Prins A, Vanhaecke T, Massie A, Balasubramaniam A, Boon P, Bourguignon JJ, Simonin F, Smolders I. Portelli J, et al. Among authors: utard v. Neuropharmacology. 2015 Aug;95:415-23. doi: 10.1016/j.neuropharm.2015.04.030. Epub 2015 May 9. Neuropharmacology. 2015. PMID: 25963417
12 results