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Hyperglycemia impairs EAAT2 glutamate transporter trafficking and glutamate clearance in islets of Langerhans: implications for type 2 diabetes pathogenesis and treatment.
Galli A, Moretti S, Dule N, Di Cairano ES, Castagna M, Marciani P, Battaglia C, Bertuzzi F, Fiorina P, Pastore I, La Rosa S, Davalli A, Folli F, Perego C. Galli A, et al. Among authors: perego c. Am J Physiol Endocrinol Metab. 2024 Jul 1;327(1):E27-E41. doi: 10.1152/ajpendo.00069.2024. Epub 2024 May 1. Am J Physiol Endocrinol Metab. 2024. PMID: 38690938
Autoantibodies against the glial glutamate transporter GLT1/EAAT2 in Type 1 diabetes mellitus-Clues to novel immunological and non-immunological therapies.
Perego C, Di Cairano ES, Galli A, Moretti S, Bazzigaluppi E, Centonze VF, Gastaldelli A, Assi E, Fiorina P, Federici M, Porzio O, Bertuzzi F, Davalli AM, Folli F. Perego C, et al. Pharmacol Res. 2022 Mar;177:106130. doi: 10.1016/j.phrs.2022.106130. Epub 2022 Feb 10. Pharmacol Res. 2022. PMID: 35151858 Free article.
The glial glutamate transporter 1 (GLT1) is expressed by pancreatic beta-cells and prevents glutamate-induced beta-cell death.
Di Cairano ES, Davalli AM, Perego L, Sala S, Sacchi VF, La Rosa S, Finzi G, Placidi C, Capella C, Conti P, Centonze VE, Casiraghi F, Bertuzzi F, Folli F, Perego C. Di Cairano ES, et al. Among authors: perego c, perego l. J Biol Chem. 2011 Apr 22;286(16):14007-18. doi: 10.1074/jbc.M110.183517. Epub 2011 Feb 18. J Biol Chem. 2011. PMID: 21335552 Free PMC article.
Mechanisms of action of incretin receptor based dual- and tri-agonists in pancreatic islets.
Folli F, Finzi G, Manfrini R, Galli A, Casiraghi F, Centofanti L, Berra C, Fiorina P, Davalli A, La Rosa S, Perego C, Higgins PB. Folli F, et al. Among authors: perego c. Am J Physiol Endocrinol Metab. 2023 Nov 1;325(5):E595-E609. doi: 10.1152/ajpendo.00236.2023. Epub 2023 Sep 20. Am J Physiol Endocrinol Metab. 2023. PMID: 37729025 Free PMC article. Review.
215 results