The small molecule inhibitor BX-795 uncouples IL-2 production from inhibition of Th2 inflammation and induces CD4+ T cells resembling iTreg.
Tauber PA, Kratzer B, Schatzlmaier P, Smole U, Köhler C, Rausch L, Kranich J, Trapin D, Neunkirchner A, Zabel M, Jutz S, Steinberger P, Gadermaier G, Brocker T, Stockinger H, Derdak S, Pickl WF.
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Front Immunol. 2023 Apr 6;14:1094694. doi: 10.3389/fimmu.2023.1094694. eCollection 2023.
Front Immunol. 2023.
PMID: 37090735
Free PMC article.