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85 results

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A forward genetic screen identifies potassium channel essentiality in SHH medulloblastoma maintenance.
Fan JJ, Erickson AW, Carrillo-Garcia J, Wang X, Skowron P, Wang X, Chen X, Shan G, Dou W, Bahrampour S, Xiong Y, Dong W, Abeysundara N, Francisco MA, Pusong RJ, Wang W, Li M, Ying E, Suárez RA, Farooq H, Holgado BL, Wu X, Daniels C, Dupuy AJ, Cadiñanos J, Bradley A, Bagchi A, Moriarity BS, Largaespada DA, Morrissy AS, Ramaswamy V, Mack SC, Garzia L, Dirks PB, Li X, Wanggou S, Egan S, Sun Y, Taylor MD, Huang X. Fan JJ, et al. Among authors: moriarity bs. Dev Cell. 2025 Jan 20:S1534-5807(25)00001-2. doi: 10.1016/j.devcel.2025.01.001. Online ahead of print. Dev Cell. 2025. PMID: 39862856
Ablation of FAS confers allogeneic CD3- CAR T cells with resistance to rejection by T cells and natural killer cells.
Menegatti S, Lopez-Cobo S, Sutra Del Galy A, Fuentealba J, Silva L, Perrin L, Heurtebise-Chrétien S, Pottez-Jouatte V, Darbois A, Burgdorf N, Privat AL, Simon A, Laprie-Sentenac M, Saitakis M, Wick B, Webber BR, Moriarity BS, Lantz O, Amigorena S, Menger L. Menegatti S, et al. Among authors: moriarity bs. Nat Biomed Eng. 2024 Dec;8(12):1651-1664. doi: 10.1038/s41551-024-01282-8. Epub 2024 Nov 18. Nat Biomed Eng. 2024. PMID: 39558141
Engineering Memory T Cells as a platform for Long-Term Enzyme Replacement Therapy in Lysosomal Storage Disorders.
Laoharawee K, Kleinboehl EW, Jensen JD, Peterson JJ, Slipek NJ, Wick BJ, Johnson MJ, Webber BR, Moriarity BS. Laoharawee K, et al. Among authors: moriarity bs. bioRxiv [Preprint]. 2024 Apr 28:2024.04.23.590790. doi: 10.1101/2024.04.23.590790. bioRxiv. 2024. Update in: Mol Ther. 2024 Nov 6;32(11):3865-3878. doi: 10.1016/j.ymthe.2024.09.033 PMID: 38712248 Free PMC article. Updated. Preprint.
Evolution of the clinical-stage hyperactive TcBuster transposase as a platform for robust non-viral production of adoptive cellular therapies.
Skeate JG, Pomeroy EJ, Slipek NJ, Jones BJ, Wick BJ, Chang JW, Lahr WS, Stelljes EM, Patrinostro X, Barnes B, Zarecki T, Krueger JB, Bridge JE, Robbins GM, McCormick MD, Leerar JR, Wenzel KT, Hornberger KM, Walker K, Smedley D, Largaespada DA, Otto N, Webber BR, Moriarity BS. Skeate JG, et al. Among authors: moriarity bs. Mol Ther. 2024 Jun 5;32(6):1817-1834. doi: 10.1016/j.ymthe.2024.04.024. Epub 2024 Apr 16. Mol Ther. 2024. PMID: 38627969 Free article.
Precision Enhancement of CAR-NK Cells through Non-Viral Engineering and Highly Multiplexed Base Editing.
Wang M, Krueger JB, Gilkey AK, Stelljes EM, Kluesner MG, Pomeroy EJ, Skeate JG, Slipek NJ, Lahr WS, Vázquez PNC, Zhao Y, Eaton EJ, Laoharawee K, Webber BR, Moriarity BS. Wang M, et al. Among authors: moriarity bs. bioRxiv [Preprint]. 2024 Mar 8:2024.03.05.582637. doi: 10.1101/2024.03.05.582637. bioRxiv. 2024. PMID: 38496503 Free PMC article. Preprint.
85 results