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Itaconate protects ferroptotic neurons by alkylating GPx4 post stroke.
Wei C, Xiao Z, Zhang Y, Luo Z, Liu D, Hu L, Shen D, Liu M, Shi L, Wang X, Lan T, Dai Q, Liu J, Chen W, Zhang Y, Sun Q, Wu W, Wang P, Zhang C, Hu J, Wang C, Yang F, Li Q. Wei C, et al. Among authors: shen d. Cell Death Differ. 2024 Aug;31(8):983-998. doi: 10.1038/s41418-024-01303-8. Epub 2024 May 8. Cell Death Differ. 2024. PMID: 38719928
IRG1/itaconate increases IL-10 release to alleviate mechanical and thermal hypersensitivity in mice after nerve injury.
Sun Q, Hu T, Zhang Y, Wang X, Liu J, Chen W, Wei C, Liu D, Wu W, Lan T, Ding Y, Luo Z, Liu M, Shen D, Xiao Z, Hu L, Pang M, Ma Y, Shi L, Wang P, Zhang J, Li Q, Yang F. Sun Q, et al. Among authors: shen d. Front Immunol. 2022 Oct 13;13:1012442. doi: 10.3389/fimmu.2022.1012442. eCollection 2022. Front Immunol. 2022. PMID: 36311727 Free PMC article.
Inhibition of the LRRC8A channel promotes microglia/macrophage phagocytosis and improves outcomes after intracerebral hemorrhagic stroke.
Liu J, Shen D, Wei C, Wu W, Luo Z, Hu L, Xiao Z, Hu T, Sun Q, Wang X, Ding Y, Liu M, Pang M, Gai K, Ma Y, Tian Y, Yu Y, Wang P, Guan Y, Xu M, Yang F, Li Q. Liu J, et al. Among authors: shen d. iScience. 2022 Nov 13;25(12):105527. doi: 10.1016/j.isci.2022.105527. eCollection 2022 Dec 22. iScience. 2022. PMID: 36465125 Free PMC article.
H3K9 trimethylation dictates neuronal ferroptosis through repressing Tfr1.
Lan T, Hu L, Sun T, Wang X, Xiao Z, Shen D, Wu W, Luo Z, Wei C, Wang X, Liu M, Guo Y, Wang L, Wang Y, Lu Y, Yu Y, Yang F, Zhang C, Li Q. Lan T, et al. Among authors: shen d. J Cereb Blood Flow Metab. 2023 Aug;43(8):1365-1381. doi: 10.1177/0271678X231165653. Epub 2023 Mar 24. J Cereb Blood Flow Metab. 2023. PMID: 36960698 Free PMC article.
5,476 results