Gu YZ - Search Results

1

Magnitude of Urine Albumin and KIM-1 Changes Can be Used to Differentiate Glomerular Injury From Tubular Injury in Rats.

Gu YZ, Paul E, Vlasakova K, Troth SP, Sistare FD, Ramaiah L, Potz O, Sutradhar S, Glaab WE. Gu YZ, et al. Toxicol Pathol. 2024 Feb;52(2-3):88-98. doi: 10.1177/01926233241248656. Epub 2024 May 14. Toxicol Pathol. 2024. PMID: 38742644 Free PMC article.

2

Performance Assessment of New Urinary Translational Safety Biomarkers of Drug-induced Renal Tubular Injury in Tenofovir-treated Cynomolgus Monkeys and Beagle Dogs.

Gu YZ, Vlasakova K, Troth SP, Peiffer RL, Tournade H, Pasello Dos Santos FR, Glaab WE, Sistare FD. Gu YZ, et al. Toxicol Pathol. 2018 Jul;46(5):553-563. doi: 10.1177/0192623318775023. Epub 2018 May 28. Toxicol Pathol. 2018. PMID: 29807506

3

Early-Onset albuminuria and Associated Renal Pathology in Leucine-Rich Repeat Kinase 2 Knockout Rats.

Gu YZ, Vlasakova K, Miller G, Gatto NT, Ciaccio PJ, Kuruvilla S, Besteman EG, Smith R, Reynolds SJ, Amin RP, Glaab WE, Wollenberg G, Lebron J, Sistare FD. Gu YZ, et al. Toxicol Pathol. 2023 Jan;51(1-2):15-26. doi: 10.1177/01926233231162809. Epub 2023 Apr 20. Toxicol Pathol. 2023. PMID: 37078689

4

Kidney Injury Monitoring in Tobramycin-Treated Rhesus Monkeys: Supplementing Urinary Kidney Biomarkers With Kidney Biopsy Gene Expression Profiling.

Gu YZ, Handt L, Vlasakova K, Bakthavatchalu V, Smith R, Fernandez GE, Born SL, Glaab WE, Sistare FD. Gu YZ, et al. Toxicol Pathol. 2022 Jan;50(1):35-46. doi: 10.1177/01926233211049171. Epub 2021 Oct 17. Toxicol Pathol. 2022. PMID: 34657537

5

Urine kidney safety biomarkers improve understanding of indirect intra-renal injury potential in dogs with a drug-induced prerenal azotemia.

Gu YZ, Vlasakova K, Darbes J, Wang E, Ferraro J, Glaab WE, Sistare FD. Gu YZ, et al. Toxicology. 2020 Jun;439:152462. doi: 10.1016/j.tox.2020.152462. Epub 2020 Apr 27. Toxicology. 2020. PMID: 32348786

6

Biomarkers in peripheral blood associated with vascular injury in Sprague-Dawley rats treated with the phosphodiesterase IV inhibitors SCH 351591 or SCH 534385.

Weaver JL, Snyder R, Knapton A, Herman EH, Honchel R, Miller T, Espandiari P, Smith R, Gu YZ, Goodsaid FM, Rosenblum IY, Sistare FD, Zhang J, Hanig J. Weaver JL, et al. Among authors: gu yz. Toxicol Pathol. 2008 Oct;36(6):840-9. doi: 10.1177/0192623308322310. Epub 2008 Sep 5. Toxicol Pathol. 2008. PMID: 18776166

7

Evaluation of the relative performance of 12 urinary biomarkers for renal safety across 22 rat sensitivity and specificity studies.

Vlasakova K, Erdos Z, Troth SP, McNulty K, Chapeau-Campredon V, Mokrzycki N, Muniappa N, Gu YZ, Holder D, Bailey WJ, Sistare FD, Glaab WE. Vlasakova K, et al. Among authors: gu yz. Toxicol Sci. 2014 Mar;138(1):3-20. doi: 10.1093/toxsci/kft330. Epub 2013 Dec 21. Toxicol Sci. 2014. PMID: 24361871

8

Rat Urinary Osteopontin and Neutrophil Gelatinase-Associated Lipocalin Improve Certainty of Detecting Drug-Induced Kidney Injury.

Phillips JA, Holder DJ, Ennulat D, Gautier JC, Sauer JM, Yang Y, McDuffie E, Sonee M, Gu YZ, Troth SP, Lynch K, Hamlin D, Peters DG, Brees D, Walker EG. Phillips JA, et al. Among authors: gu yz. Toxicol Sci. 2016 Jun;151(2):214-23. doi: 10.1093/toxsci/kfw038. Epub 2016 Mar 28. Toxicol Sci. 2016. PMID: 27026710

9

Towards consensus practices to qualify safety biomarkers for use in early drug development.

Sistare FD, Dieterle F, Troth S, Holder DJ, Gerhold D, Andrews-Cleavenger D, Baer W, Betton G, Bounous D, Carl K, Collins N, Goering P, Goodsaid F, Gu YZ, Guilpin V, Harpur E, Hassan A, Jacobson-Kram D, Kasper P, Laurie D, Lima BS, Maciulaitis R, Mattes W, Maurer G, Obert LA, Ozer J, Papaluca-Amati M, Phillips JA, Pinches M, Schipper MJ, Thompson KL, Vamvakas S, Vidal JM, Vonderscher J, Walker E, Webb C, Yu Y. Sistare FD, et al. Among authors: gu yz. Nat Biotechnol. 2010 May;28(5):446-54. doi: 10.1038/nbt.1634. Epub 2010 May 10. Nat Biotechnol. 2010. PMID: 20458314

10

Polyethlyene Glycol 200 Can Protect Rats Against Drug-Induced Kidney Toxicity Through Inhibition of the Renal Organic Anion Transporter 3.

Gu YZ, Chu X, Houle R, Vlasakova K, Koeplinger KA, Bourgeois I, Palyada K, Anderson KD, Brynczka C, Bhatt B, Chen F, Smith R, Amin R, Glaab WE, Lebron J, Cox K, Sistare FD. Gu YZ, et al. Toxicol Sci. 2019 Nov 1;172(1):155-166. doi: 10.1093/toxsci/kfz186. Toxicol Sci. 2019. PMID: 31406999

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