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Page 1
Renal L-2-hydroxyglutarate dehydrogenase activity promotes hypoxia tolerance and mitochondrial metabolism in Drosophila melanogaster.
Mahmoudzadeh NH, Heidarian Y, Tourigny JP, Fitt AJ, Beebe K, Li H, Luhur A, Buddika K, Mungcal L, Kundu A, Policastro RA, Brinkley GJ, Zentner GE, Nemkov T, Pepin R, Chawla G, Sudarshan S, Rodan AR, D'Alessandro A, Tennessen JM. Mahmoudzadeh NH, et al. Mol Metab. 2024 Nov;89:102013. doi: 10.1016/j.molmet.2024.102013. Epub 2024 Aug 23. Mol Metab. 2024. PMID: 39182840 Free PMC article.
l-2-Hydroxyglutarate remodeling of the epigenome and epitranscriptome creates a metabolic vulnerability in kidney cancer models.
Kundu A, Brinkley GJ, Nam H, Karki S, Kirkman R, Pandit M, Shim E, Widden H, Liu J, Heidarian Y, Mahmoudzadeh NH, Fitt AJ, Absher D, Ding HF, Crossman DK, Placzek WJ, Locasale JW, Rakheja D, McConathy JE, Ramachandran R, Bae S, Tennessen JM, Sudarshan S. Kundu A, et al. Among authors: mahmoudzadeh nh. J Clin Invest. 2024 May 14;134(13):e171294. doi: 10.1172/JCI171294. J Clin Invest. 2024. PMID: 38743486 Free PMC article.
Metabolomic analysis of Drosophila melanogaster larvae lacking pyruvate kinase.
Heidarian Y, Tourigny JP, Fasteen TD, Mahmoudzadeh NH, Hurlburt AJ, Nemkov T, Reisz JA, D'Alessandro A, Tennessen JM. Heidarian Y, et al. Among authors: mahmoudzadeh nh. G3 (Bethesda). 2023 Dec 29;14(1):jkad228. doi: 10.1093/g3journal/jkad228. G3 (Bethesda). 2023. PMID: 37792629 Free PMC article.
Metabolomic analysis of Drosophila melanogaster larvae lacking Pyruvate kinase.
Heidarian Y, Tourigny JP, Fasteen TD, Mahmoudzadeh NH, Hurlburt AJ, Nemkov T, Reisz JA, D'Alessandro A, Tennessen JM. Heidarian Y, et al. Among authors: mahmoudzadeh nh. bioRxiv [Preprint]. 2023 Jun 19:2023.06.05.543743. doi: 10.1101/2023.06.05.543743. bioRxiv. 2023. Update in: G3 (Bethesda). 2023 Dec 29;14(1):jkad228. doi: 10.1093/g3journal/jkad228 PMID: 37333180 Free PMC article. Updated. Preprint.
The oncometabolite L-2-hydroxyglutarate is a common product of dipteran larval development.
Mahmoudzadeh NH, Fitt AJ, Schwab DB, Martenis WE, Nease LM, Owings CG, Brinkley GJ, Li H, Karty JA, Sudarshan S, Hardy RW, Moczek AP, Picard CJ, Tennessen JM. Mahmoudzadeh NH, et al. Insect Biochem Mol Biol. 2020 Dec;127:103493. doi: 10.1016/j.ibmb.2020.103493. Epub 2020 Nov 3. Insect Biochem Mol Biol. 2020. PMID: 33157229 Free PMC article.
Lactate dehydrogenase and glycerol-3-phosphate dehydrogenase cooperatively regulate growth and carbohydrate metabolism during Drosophila melanogaster larval development.
Li H, Rai M, Buddika K, Sterrett MC, Luhur A, Mahmoudzadeh NH, Julick CR, Pletcher RC, Chawla G, Gosney CJ, Burton AK, Karty JA, Montooth KL, Sokol NS, Tennessen JM. Li H, et al. Among authors: mahmoudzadeh nh. Development. 2019 Sep 12;146(17):dev175315. doi: 10.1242/dev.175315. Development. 2019. PMID: 31399469 Free PMC article.