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l-2-Hydroxyglutarate remodeling of the epigenome and epitranscriptome creates a metabolic vulnerability in kidney cancer models.
Kundu A, Brinkley GJ, Nam H, Karki S, Kirkman R, Pandit M, Shim E, Widden H, Liu J, Heidarian Y, Mahmoudzadeh NH, Fitt AJ, Absher D, Ding HF, Crossman DK, Placzek WJ, Locasale JW, Rakheja D, McConathy JE, Ramachandran R, Bae S, Tennessen JM, Sudarshan S. Kundu A, et al. Among authors: rakheja d. J Clin Invest. 2024 May 14;134(13):e171294. doi: 10.1172/JCI171294. J Clin Invest. 2024. PMID: 38743486 Free PMC article.
KLF13 promotes SLE pathogenesis by modifying chromatin accessibility of key proinflammatory cytokine genes.
Wang A, Fairhurst AM, Liu K, Wakeland B, Barnes S, Malladi VS, Viswanathan K, Arana C, Dozmorov I, Singhar A, Du Y, Imam M, Moses A, Chen C, Sunkavalli A, Casco J, Rakheja D, Li QZ, Mohan C, Clayberger C, Wakeland EK, Khan S. Wang A, et al. Among authors: rakheja d. Commun Biol. 2024 Nov 6;7(1):1446. doi: 10.1038/s42003-024-07099-0. Commun Biol. 2024. PMID: 39506084 Free PMC article.
Melanoma antigens in pediatric medulloblastoma contribute to tumor heterogeneity and species-specificity of group 3 tumors.
Collins RRJ, Gee RRF, Sanchez MCH, Tozandehjani S, Bayat T, Breznik B, Lee AK, Peters ST, Connelly JP, Pruett-Miller SM, Roussel MF, Rakheja D, Tillman HS, Potts PR, Fon Tacer K. Collins RRJ, et al. Among authors: rakheja d. bioRxiv [Preprint]. 2024 May 17:2024.05.14.594201. doi: 10.1101/2024.05.14.594201. bioRxiv. 2024. PMID: 38798351 Free PMC article. Preprint.
Comparative genomics incorporating translocation renal cell carcinoma mouse model reveals molecular mechanisms of tumorigenesis.
Prakasam G, Mishra A, Christie A, Miyata J, Carrillo D, Tcheuyap VT, Ye H, Do QN, Wang Y, Reig Torras O, Butti R, Zhong H, Gagan J, Jones KB, Carroll TJ, Modrusan Z, Durinck S, Requena-Komuro MC, Williams NS, Pedrosa I, Wang T, Rakheja D, Kapur P, Brugarolas J. Prakasam G, et al. Among authors: rakheja d. J Clin Invest. 2024 Feb 22;134(7):e170559. doi: 10.1172/JCI170559. J Clin Invest. 2024. PMID: 38386415 Free PMC article.
Osteosarcoma Explorer: A Data Commons With Clinical, Genomic, Protein, and Tissue Imaging Data for Osteosarcoma Research.
Yang DM, Zhou Q, Furman-Cline L, Cheng X, Luo D, Lai H, Li Y, Jin KW, Yao B, Leavey PJ, Rakheja D, Lo T, Hall D, Barkauskas DA, Shulman DS, Janeway K, Khanna C, Gorlick R, Menzies C, Zhan X, Xiao G, Skapek SX, Xu L, Klesse LJ, Crompton BD, Xie Y. Yang DM, et al. Among authors: rakheja d. JCO Clin Cancer Inform. 2023 Sep;7:e2300104. doi: 10.1200/CCI.23.00104. JCO Clin Cancer Inform. 2023. PMID: 37956387 Free PMC article.
Target-directed microRNA degradation regulates developmental microRNA expression and embryonic growth in mammals.
Jones BT, Han J, Zhang H, Hammer RE, Evers BM, Rakheja D, Acharya A, Mendell JT. Jones BT, et al. Among authors: rakheja d. bioRxiv [Preprint]. 2023 Jun 26:2023.06.26.546601. doi: 10.1101/2023.06.26.546601. bioRxiv. 2023. Update in: Genes Dev. 2023 Jul 1;37(13-14):661-674. doi: 10.1101/gad.350906.123 PMID: 37425885 Free PMC article. Updated. Preprint.
200 results