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l-2-Hydroxyglutarate remodeling of the epigenome and epitranscriptome creates a metabolic vulnerability in kidney cancer models.
Kundu A, Brinkley GJ, Nam H, Karki S, Kirkman R, Pandit M, Shim E, Widden H, Liu J, Heidarian Y, Mahmoudzadeh NH, Fitt AJ, Absher D, Ding HF, Crossman DK, Placzek WJ, Locasale JW, Rakheja D, McConathy JE, Ramachandran R, Bae S, Tennessen JM, Sudarshan S. Kundu A, et al. Among authors: widden h. J Clin Invest. 2024 May 14;134(13):e171294. doi: 10.1172/JCI171294. J Clin Invest. 2024. PMID: 38743486 Free PMC article.
A cell-penetrating MARCKS mimetic selectively triggers cytolytic death in glioblastoma.
Eustace NJ, Anderson JC, Warram JM, Widden HN, Pedersen RT, Alrefai H, Patel Z, Hicks PH, Placzek WJ, Gillespie GY, Hjelmeland AB, Willey CD. Eustace NJ, et al. Among authors: widden hn. Oncogene. 2020 Nov;39(46):6961-6974. doi: 10.1038/s41388-020-01511-9. Epub 2020 Oct 19. Oncogene. 2020. PMID: 33077834 Free PMC article.