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Discovery of CRBN-dependent WEE1 Molecular Glue Degraders from a Multicomponent Combinatorial Library.
Razumkov H, Jiang Z, Baek K, You I, Geng Q, Donovan KA, Tang MT, Metivier RJ, Mageed N, Seo P, Li Z, Byun WS, Hinshaw SM, Sarott RC, Fischer ES, Gray NS. Razumkov H, et al. Among authors: seo p. bioRxiv [Preprint]. 2024 May 5:2024.05.04.592550. doi: 10.1101/2024.05.04.592550. bioRxiv. 2024. Update in: J Am Chem Soc. 2024 Nov 20;146(46):31433-31443. doi: 10.1021/jacs.4c06127 PMID: 38746375 Free PMC article. Updated. Preprint.
Targeted kinase degradation via the KLHDC2 ubiquitin E3 ligase.
Kim Y, Seo P, Jeon E, You I, Hwang K, Kim N, Tse J, Bae J, Choi HS, Hinshaw SM, Gray NS, Sim T. Kim Y, et al. Among authors: seo p. Cell Chem Biol. 2023 Nov 16;30(11):1414-1420.e5. doi: 10.1016/j.chembiol.2023.07.008. Epub 2023 Aug 10. Cell Chem Biol. 2023. PMID: 37567174 Free PMC article.
Chemical Specification of E3 Ubiquitin Ligase Engagement by Cysteine-Reactive Chemistry.
Sarott RC, You I, Li YD, Toenjes ST, Donovan KA, Seo P, Ordonez M, Byun WS, Hassan MM, Wachter F, Chouchani ET, Słabicki M, Fischer ES, Ebert BL, Hinshaw SM, Gray NS. Sarott RC, et al. Among authors: seo p. J Am Chem Soc. 2023 Oct 11;145(40):21937-21944. doi: 10.1021/jacs.3c06622. Epub 2023 Sep 28. J Am Chem Soc. 2023. PMID: 37767920
PBBM Considerations for Base Models, Model Validation, and Application Steps: Workshop Summary Report.
Heimbach T, Musuamba Tshinanu F, Raines K, Borges L, Kijima S, Malamatari M, Moody R, Veerasingham S, Seo P, Turner D, Fang L, Stillhart C, Bransford P, Ren X, Patel N, Sperry D, Chen H, Rostami-Hodjegan A, Lukacova V, Sun D, Nguefack JF, Carducci T, Grimstein M, Pepin X, Jamei M, Stamatopoulos K, Li M, Sanghavi M, Tannergren C, Mandula H, Zhao Z, Ju TR, Wagner C, Arora S, Wang M, Rullo G, Mitra A, Kollipara S, Chirumamilla SK, Polli JE, Mackie C. Heimbach T, et al. Among authors: seo p. Mol Pharm. 2024 Nov 4;21(11):5353-5372. doi: 10.1021/acs.molpharmaceut.4c00758. Epub 2024 Sep 30. Mol Pharm. 2024. PMID: 39348508 Free PMC article. Review.
757 results