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Combined genetic-pharmacologic inactivation of tightly linked ADAMTS proteases in temporally specific windows uncovers distinct roles for versican proteolysis and glypican-6 in cardiac development.
Mead TJ, Bhutada S, Foulcer SJ, Peruzzi N, Nelson CM, Seifert DE, Larkin J, Tran-Lundmark K, Filmus J, Apte SS. Mead TJ, et al. Among authors: seifert de. Matrix Biol. 2024 Aug;131:1-16. doi: 10.1016/j.matbio.2024.05.003. Epub 2024 May 13. Matrix Biol. 2024. PMID: 38750698 Free PMC article.
ADAMTSL3 knock-out mice develop cardiac dysfunction and dilatation with increased TGFβ signalling after pressure overload.
Rypdal KB, Olav Melleby A, Robinson EL, Li J, Palmero S, Seifert DE, Martin D, Clark C, López B, Andreassen K, Dahl CP, Sjaastad I, Tønnessen T, Stokke MK, Louch WE, González A, Heymans S, Christensen G, Apte SS, Lunde IG. Rypdal KB, et al. Among authors: seifert de. Commun Biol. 2022 Dec 20;5(1):1392. doi: 10.1038/s42003-022-04361-1. Commun Biol. 2022. PMID: 36539599 Free PMC article.