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Dynamic microfluidic single-cell screening identifies pheno-tuning compounds to potentiate tuberculosis therapy.
Mistretta M, Cimino M, Campagne P, Volant S, Kornobis E, Hebert O, Rochais C, Dallemagne P, Lecoutey C, Tisnerat C, Lepailleur A, Ayotte Y, LaPlante SR, Gangneux N, Záhorszká M, Korduláková J, Vichier-Guerre S, Bonhomme F, Pokorny L, Albert M, Tinevez JY, Manina G. Mistretta M, et al. Among authors: manina g. Nat Commun. 2024 May 16;15(1):4175. doi: 10.1038/s41467-024-48269-2. Nat Commun. 2024. PMID: 38755132 Free PMC article.
6,11-Dioxobenzo[f]pyrido[1,2-a]indoles Kill Mycobacterium tuberculosis by Targeting Iron-Sulfur Protein Rv0338c (IspQ), A Putative Redox Sensor.
Székely R, Rengifo-Gonzalez M, Singh V, Riabova O, Benjak A, Piton J, Cimino M, Kornobis E, Mizrahi V, Johnsson K, Manina G, Makarov V, Cole ST. Székely R, et al. Among authors: manina g. ACS Infect Dis. 2020 Nov 13;6(11):3015-3025. doi: 10.1021/acsinfecdis.0c00531. Epub 2020 Oct 1. ACS Infect Dis. 2020. PMID: 32930569 Free article.
Phenotypic Heterogeneity in Mycobacterium tuberculosis.
Dhar N, McKinney J, Manina G. Dhar N, et al. Among authors: manina g. Microbiol Spectr. 2016 Nov;4(6). doi: 10.1128/microbiolspec.TBTB2-0021-2016. Microbiol Spectr. 2016. PMID: 27837741 Free article. Review.
Listeriolysin S: A bacteriocin from Listeria monocytogenes that induces membrane permeabilization in a contact-dependent manner.
Meza-Torres J, Lelek M, Quereda JJ, Sachse M, Manina G, Ershov D, Tinevez JY, Radoshevich L, Maudet C, Chaze T, Giai Gianetto Q, Matondo M, Lecuit M, Martin-Verstraete I, Zimmer C, Bierne H, Dussurget O, Cossart P, Pizarro-Cerdá J. Meza-Torres J, et al. Among authors: manina g. Proc Natl Acad Sci U S A. 2021 Oct 5;118(40):e2108155118. doi: 10.1073/pnas.2108155118. Proc Natl Acad Sci U S A. 2021. PMID: 34599102 Free PMC article.
Benzothiazinones kill Mycobacterium tuberculosis by blocking arabinan synthesis.
Makarov V, Manina G, Mikusova K, Möllmann U, Ryabova O, Saint-Joanis B, Dhar N, Pasca MR, Buroni S, Lucarelli AP, Milano A, De Rossi E, Belanova M, Bobovska A, Dianiskova P, Kordulakova J, Sala C, Fullam E, Schneider P, McKinney JD, Brodin P, Christophe T, Waddell S, Butcher P, Albrethsen J, Rosenkrands I, Brosch R, Nandi V, Bharath S, Gaonkar S, Shandil RK, Balasubramanian V, Balganesh T, Tyagi S, Grosset J, Riccardi G, Cole ST. Makarov V, et al. Among authors: manina g. Science. 2009 May 8;324(5928):801-4. doi: 10.1126/science.1171583. Epub 2009 Mar 19. Science. 2009. PMID: 19299584 Free PMC article.
36 results