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388 results

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Page 1
A chemical probe to modulate human GID4 Pro/N-degron interactions.
Owens DDG, Maitland MER, Khalili Yazdi A, Song X, Reber V, Schwalm MP, Machado RAC, Bauer N, Wang X, Szewczyk MM, Dong C, Dong A, Loppnau P, Calabrese MF, Dowling MS, Lee J, Montgomery JI, O'Connell TN, Subramanyam C, Wang F, Adamson EC, Schapira M, Gstaiger M, Knapp S, Vedadi M, Min J, Lajoie GA, Barsyte-Lovejoy D, Owen DR, Schild-Poulter C, Arrowsmith CH. Owens DDG, et al. Among authors: arrowsmith ch. Nat Chem Biol. 2024 Sep;20(9):1164-1175. doi: 10.1038/s41589-024-01618-0. Epub 2024 May 21. Nat Chem Biol. 2024. PMID: 38773330
Chemical screening methods to identify ligands that promote protein stability, protein crystallization, and structure determination.
Vedadi M, Niesen FH, Allali-Hassani A, Fedorov OY, Finerty PJ Jr, Wasney GA, Yeung R, Arrowsmith C, Ball LJ, Berglund H, Hui R, Marsden BD, Nordlund P, Sundstrom M, Weigelt J, Edwards AM. Vedadi M, et al. Proc Natl Acad Sci U S A. 2006 Oct 24;103(43):15835-40. doi: 10.1073/pnas.0605224103. Epub 2006 Oct 11. Proc Natl Acad Sci U S A. 2006. PMID: 17035505 Free PMC article.
Structural and chemical profiling of the human cytosolic sulfotransferases.
Allali-Hassani A, Pan PW, Dombrovski L, Najmanovich R, Tempel W, Dong A, Loppnau P, Martin F, Thornton J, Edwards AM, Bochkarev A, Plotnikov AN, Vedadi M, Arrowsmith CH. Allali-Hassani A, et al. Among authors: arrowsmith ch. PLoS Biol. 2007 May;5(5):e97. doi: 10.1371/journal.pbio.0050097. PLoS Biol. 2007. PMID: 17425406 Free PMC article.
CUL7 is a novel antiapoptotic oncogene.
Kim SS, Shago M, Kaustov L, Boutros PC, Clendening JW, Sheng Y, Trentin GA, Barsyte-Lovejoy D, Mao DY, Kay R, Jurisica I, Arrowsmith CH, Penn LZ. Kim SS, et al. Among authors: arrowsmith ch. Cancer Res. 2007 Oct 15;67(20):9616-22. doi: 10.1158/0008-5472.CAN-07-0644. Cancer Res. 2007. PMID: 17942889
In situ proteolysis for protein crystallization and structure determination.
Dong A, Xu X, Edwards AM; Midwest Center for Structural Genomics; Structural Genomics Consortium; Chang C, Chruszcz M, Cuff M, Cymborowski M, Di Leo R, Egorova O, Evdokimova E, Filippova E, Gu J, Guthrie J, Ignatchenko A, Joachimiak A, Klostermann N, Kim Y, Korniyenko Y, Minor W, Que Q, Savchenko A, Skarina T, Tan K, Yakunin A, Yee A, Yim V, Zhang R, Zheng H, Akutsu M, Arrowsmith C, Avvakumov GV, Bochkarev A, Dahlgren LG, Dhe-Paganon S, Dimov S, Dombrovski L, Finerty P Jr, Flodin S, Flores A, Gräslund S, Hammerström M, Herman MD, Hong BS, Hui R, Johansson I, Liu Y, Nilsson M, Nedyalkova L, Nordlund P, Nyman T, Min J, Ouyang H, Park HW, Qi C, Rabeh W, Shen L, Shen Y, Sukumard D, Tempel W, Tong Y, Tresagues L, Vedadi M, Walker JR, Weigelt J, Welin M, Wu H, Xiao T, Zeng H, Zhu H. Dong A, et al. Nat Methods. 2007 Dec;4(12):1019-21. doi: 10.1038/nmeth1118. Epub 2007 Nov 4. Nat Methods. 2007. PMID: 17982461 Free PMC article.
L3MBTL1 recognition of mono- and dimethylated histones.
Min J, Allali-Hassani A, Nady N, Qi C, Ouyang H, Liu Y, MacKenzie F, Vedadi M, Arrowsmith CH. Min J, et al. Among authors: arrowsmith ch. Nat Struct Mol Biol. 2007 Dec;14(12):1229-30. doi: 10.1038/nsmb1340. Epub 2007 Nov 18. Nat Struct Mol Biol. 2007. PMID: 18026117
Structural genomics and drug discovery: all in the family.
Weigelt J, McBroom-Cerajewski LD, Schapira M, Zhao Y, Arrowsmith CH. Weigelt J, et al. Among authors: arrowsmith ch. Curr Opin Chem Biol. 2008 Feb;12(1):32-9. doi: 10.1016/j.cbpa.2008.01.045. Epub 2008 Mar 7. Curr Opin Chem Biol. 2008. PMID: 18282486 Review.
Human HDAC7 harbors a class IIa histone deacetylase-specific zinc binding motif and cryptic deacetylase activity.
Schuetz A, Min J, Allali-Hassani A, Schapira M, Shuen M, Loppnau P, Mazitschek R, Kwiatkowski NP, Lewis TA, Maglathin RL, McLean TH, Bochkarev A, Plotnikov AN, Vedadi M, Arrowsmith CH. Schuetz A, et al. Among authors: arrowsmith ch. J Biol Chem. 2008 Apr 25;283(17):11355-63. doi: 10.1074/jbc.M707362200. Epub 2008 Feb 19. J Biol Chem. 2008. PMID: 18285338 Free PMC article.
388 results