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Single nuclei RNA-seq reveals a medium spiny neuron glutamate excitotoxicity signature prior to the onset of neuronal death in an ovine Huntington's disease model.
Jiang A, You L, Handley RR, Hawkins V, Reid SJ, Jacobsen JC, Patassini S, Rudiger SR, Mclaughlan CJ, Kelly JM, Verma PJ, Bawden CS, Gusella JF, MacDonald ME, Waldvogel HJ, Faull RLM, Lehnert K, Snell RG. Jiang A, et al. Among authors: handley rr. Hum Mol Genet. 2024 Aug 18;33(17):1524-1539. doi: 10.1093/hmg/ddae087. Hum Mol Genet. 2024. PMID: 38776957 Free PMC article.
Further molecular characterisation of the OVT73 transgenic sheep model of Huntington's disease identifies cortical aggregates.
Huntington's Disease Sheep Collaborative Research Group; Reid SJ, Patassini S, Handley RR, Rudiger SR, McLaughlan CJ, Osmand A, Jacobsen JC, Morton AJ, Weiss A, Waldvogel HJ, MacDonald ME, Gusella JF, Bawden CS, Faull RL, Snell RG. Huntington's Disease Sheep Collaborative Research Group, et al. Among authors: handley rr. J Huntingtons Dis. 2013;2(3):279-95. doi: 10.3233/JHD-130067. J Huntingtons Dis. 2013. PMID: 25062676
Brain urea increase is an early Huntington's disease pathogenic event observed in a prodromal transgenic sheep model and HD cases.
Handley RR, Reid SJ, Brauning R, Maclean P, Mears ER, Fourie I, Patassini S, Cooper GJS, Rudiger SR, McLaughlan CJ, Verma PJ, Gusella JF, MacDonald ME, Waldvogel HJ, Bawden CS, Faull RLM, Snell RG. Handley RR, et al. Proc Natl Acad Sci U S A. 2017 Dec 26;114(52):E11293-E11302. doi: 10.1073/pnas.1711243115. Epub 2017 Dec 11. Proc Natl Acad Sci U S A. 2017. PMID: 29229845 Free PMC article.
A Multi-Omic Huntington's Disease Transgenic Sheep-Model Database for Investigating Disease Pathogenesis.
Mears ER, Handley RR, Grant MJ, Reid SJ, Day BT, Rudiger SR, McLaughlan CJ, Verma PJ, Bawden SC, Patassini S, Unwin RD, Cooper GJS, Gusella JF, MacDonald ME, Brauning R, Maclean P, Pearson JF, Waldvogel HJ, Faull RLM, Snell RG. Mears ER, et al. Among authors: handley rr. J Huntingtons Dis. 2021;10(4):423-434. doi: 10.3233/JHD-210482. J Huntingtons Dis. 2021. PMID: 34420978 Free PMC article.
Potential molecular consequences of transgene integration: The R6/2 mouse example.
Jacobsen JC, Erdin S, Chiang C, Hanscom C, Handley RR, Barker DD, Stortchevoi A, Blumenthal I, Reid SJ, Snell RG, MacDonald ME, Morton AJ, Ernst C, Gusella JF, Talkowski ME. Jacobsen JC, et al. Among authors: handley rr. Sci Rep. 2017 Jan 25;7:41120. doi: 10.1038/srep41120. Sci Rep. 2017. PMID: 28120936 Free PMC article.
Alzheimer's disease markers in the aged sheep (Ovis aries).
Reid SJ, Mckean NE, Henty K, Portelius E, Blennow K, Rudiger SR, Bawden CS, Handley RR, Verma PJ, Faull RLM, Waldvogel HJ, Zetterberg H, Snell RG. Reid SJ, et al. Among authors: handley rr. Neurobiol Aging. 2017 Oct;58:112-119. doi: 10.1016/j.neurobiolaging.2017.06.020. Epub 2017 Jun 24. Neurobiol Aging. 2017. PMID: 28728117
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