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Page 1
Repurposing drugs targeting epidemic viruses.
Namasivayam V, Palaniappan S, Vanangamudi M. Namasivayam V, et al. Drug Discov Today. 2022 Jul;27(7):1874-1894. doi: 10.1016/j.drudis.2022.04.008. Epub 2022 Apr 12. Drug Discov Today. 2022. PMID: 35427764 Review.
Cell-permeable high-affinity tracers for Gq proteins provide structural insights, reveal distinct binding kinetics and identify small molecule inhibitors.
Kuschak M, Namasivayam V, Rafehi M, Voss JH, Garg J, Schlegel JG, Abdelrahman A, Kehraus S, Reher R, Küppers J, Sylvester K, Hinz S, Matthey M, Wenzel D, Fleischmann BK, Pfeifer A, Inoue A, Gütschow M, König GM, Müller CE. Kuschak M, et al. Among authors: namasivayam v. Br J Pharmacol. 2020 Apr;177(8):1898-1916. doi: 10.1111/bph.14960. Epub 2020 Feb 11. Br J Pharmacol. 2020. PMID: 31881095 Free PMC article.
Radiosynthesis and in vivo evaluation of a fluorine-18 labeled pyrazine based radioligand for PET imaging of the adenosine A2B receptor.
Lindemann M, Hinz S, Deuther-Conrad W, Namasivayam V, Dukic-Stefanovic S, Teodoro R, Toussaint M, Kranz M, Juhl C, Steinbach J, Brust P, Müller CE, Wenzel B. Lindemann M, et al. Among authors: namasivayam v. Bioorg Med Chem. 2018 Sep 1;26(16):4650-4663. doi: 10.1016/j.bmc.2018.07.045. Epub 2018 Jul 29. Bioorg Med Chem. 2018. PMID: 30104122
Inhibition of cellular RNA methyltransferase abrogates influenza virus capping and replication.
Tsukamoto Y, Hiono T, Yamada S, Matsuno K, Faist A, Claff T, Hou J, Namasivayam V, Vom Hemdt A, Sugimoto S, Ng JY, Christensen MH, Tesfamariam YM, Wolter S, Juranek S, Zillinger T, Bauer S, Hirokawa T, Schmidt FI, Kochs G, Shimojima M, Huang YS, Pichlmair A, Kümmerer BM, Sakoda Y, Schlee M, Brunotte L, Müller CE, Igarashi M, Kato H. Tsukamoto Y, et al. Among authors: namasivayam v. Science. 2023 Feb 10;379(6632):586-591. doi: 10.1126/science.add0875. Epub 2023 Feb 9. Science. 2023. PMID: 36758070
2-Substituted thienotetrahydropyridine derivatives: Allosteric ectonucleotidase inhibitors.
Schäkel L, Mirza S, Pietsch M, Lee SY, Keuler T, Sylvester K, Pelletier J, Sévigny J, Pillaiyar T, Namasivayam V, Gütschow M, Müller CE. Schäkel L, et al. Among authors: namasivayam v. Arch Pharm (Weinheim). 2021 Dec;354(12):e2100300. doi: 10.1002/ardp.202100300. Epub 2021 Oct 26. Arch Pharm (Weinheim). 2021. PMID: 34697820
Structure-Activity Relationship of Purine and Pyrimidine Nucleotides as Ecto-5'-Nucleotidase (CD73) Inhibitors.
Junker A, Renn C, Dobelmann C, Namasivayam V, Jain S, Losenkova K, Irjala H, Duca S, Balasubramanian R, Chakraborty S, Börgel F, Zimmermann H, Yegutkin GG, Müller CE, Jacobson KA. Junker A, et al. Among authors: namasivayam v. J Med Chem. 2019 Apr 11;62(7):3677-3695. doi: 10.1021/acs.jmedchem.9b00164. Epub 2019 Mar 21. J Med Chem. 2019. PMID: 30895781 Free PMC article.
Cancer cells adapt FAM134B/BiP mediated ER-phagy to survive hypoxic stress.
Chipurupalli S, Ganesan R, Martini G, Mele L, Reggio A, Esposito M, Kannan E, Namasivayam V, Grumati P, Desiderio V, Robinson N. Chipurupalli S, et al. Among authors: namasivayam v. Cell Death Dis. 2022 Apr 18;13(4):357. doi: 10.1038/s41419-022-04813-w. Cell Death Dis. 2022. PMID: 35436985 Free PMC article.
117 results